Foundational Porcine Stem Cells and Genetic Tools for Large-Animal Models
Official title: Foundational Porcine Stem Cell and Genetic Tools to Enable Rigorous, Reproducible Generation of Large-Animal Models
Funded at University of Missouri-Columbia · NIH-11421283 · Data updated 2026-11-12
A project to develop pig stem cells and precise genetic tools to create and study large-animal models that better resemble human biology.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Missouri-Columbia NIH-funded |
| Lab location | 1 site (Columbia, United States) |
| Project start | August 1, 2026 |
| Project end | April 30, 2030 |
| Funding year | 2026 |
| Award (this year) | $774,021 |
| NIH project number | 1R24OD042576-01 |
| Project ID | NIH-11421283 on NIH RePORTER |
Who could benefit from this research
✓Could help
Not applicable for this grant itself; this is a preclinical infrastructure grant focused on animal models.
✕Less likely to help
No direct patient participation or immediate clinical benefit from this grant.
What this research studies
This NIH grant focuses on creating reliable pig stem cell lines and genetic methods that allow precise, large-scale genetic modifications. By establishing landing pads and recombinase-based systems in pig cells, researchers aim to build better animal models for studying diseases and for xenotransplantation. The work will enable iterative genetic changes to produce complex pig models that can mimic human conditions more closely than mice. The ultimate goal is to accelerate adoption of pig models in biomedical research and pave the way for translational studies.
Why it matters
Potential benefit: If successful, patients could benefit from improved disease models that speed up the development of therapies and transplantation options.
How similar studies have gone: Previous work in mice and initial porcine models suggests that advanced genetic tools can enable more accurate disease models, but pig-specific ESC lines are still being developed.
Where this research is happening
-
University of Missouri-Columbia
Columbia, United States Active
Researchers
- Principal investigator: Telugu, Bhanu Prakash — University of Missouri-Columbia
- Study coordinator: Telugu, Bhanu Prakash
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.