Improving recovery after hand transplantation and nerve injuries using brain stimulation

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to enhance functional recovery in patients with upper extremity nerve injuries by combining behavioral training with transcranial direct current stimulation (tDCS), a non-invasive brain stimulation technique. The approach is based on recent neuroscience discoveries that suggest adaptive brain plasticity can be harnessed to improve rehabilitation outcomes. Participants will be individuals who have undergone hand transplantation or nerve repair and are in the chronic recovery phase, approximately 12 to 18 months post-surgery. The study will evaluate the effectiveness of this innovative rehabilitation program compared to standard care.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Individuals whom have received a unilateral allogeneic transplantation proximal to the wrist and are at the chronic stage of recovery (approx. 12 - 18 months following surgery, when Tinel's sign reaches the distal fingertips).
* Individuals whom have undergone a complete amputation the hand between the wrist and elbow followed by successful re-attachment and are at the chronic stage of recovery (approx. 12 - 18 months following surgery, when Tinel's sign reaches the distal fingertips).
* Individuals whom have undergone repairs of the median, ulnar, or other related or nearby nerve(s) following complex volar forearm lacerations or other injuries between the distal wrist crease and the flexor musculotendinous junctions. Individuals must be at the chronic stage of recovery (approx. 12 - 18 months following surgery, when Tinel's sign reaches the distal fingertips).

Exclusion Criteria:

* Individuals with significant/severe brain trauma
* Serious psychiatric conditions
* Chronic or severe neurological conditions.
* Current pregnancy
* History of seizures or unexplained loss of consciousness
* Metallic implants above the chest
* Certain implanted medical devices.

Where it's running

• Christine Kleinert Institute for Hand & Microsurgery
  Louisville, Kentucky, United States Recruiting
• University of Missouri
  Columbia, Missouri, United States Recruiting
• Washington University School of Medicine
  St Louis, Missouri, United States Recruiting

Study contacts

• Principal investigator: Scott H Frey, Ph.D., Ed.M. — University of Missouri-Columbia
• Study coordinator: Scott H Frey, Ph.D., Ed.M.
• Email: freylab@missouri.edu
• Phone: 573-882-4572

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• High-Intensity Peripheral Magnetic Stimulation for Traumatic Nerve Injury

  This study tests whether adding high-intensity peripheral magnetic stimulation to a structured exercise program can reduce pain and improve function for adults with a traumatic peripheral nerve injury.

  Recruiting Gaziler Physical Medicine and Rehabilitation Education and Research Hospital · Ankara · NCT07705490

• Allay Hydrogel Cap: Safety and Performance in Peripheral Nerve Surgery

  This registry is watching how well the Allay Hydrogel Cap works and how safe it is for people who have peripheral nerve injuries and get the cap during surgery.

  Recruiting at 5 sites Tulavi Therapeutics,Inc. · Redwood City, California and 4 other locations · NCT07246980

• Expanding use of the Symani robotic system for peripheral nerve repair in the hand

  This study will test whether the Symani robotic surgical system can safely and effectively repair recent traumatic sensory nerve cuts in adult fingers.

  Recruiting MMI (Medical Microinstruments, Inc.) · Ludwigshafen · NCT07084207

• VMD-3866 topical gel for chemotherapy-induced nerve pain

  This trial will test whether a non-opioid topical gel called VMD-3866 can reduce pain in adults with chemotherapy-induced peripheral neuropathy.

  Recruiting Phase 2 VM Therapeutics LLC · London, UK · NCT07072468

• Using electrical stimulation to improve arm function after spinal cord injuries

  This study is testing if a special therapy using electrical stimulation can help people with spinal cord injuries improve their arm function and everyday activities.

  Recruiting University of Miami · Miami, Florida · NCT06672458

• Comparing different methods for repairing peripheral nerve injuries

  This study is testing three different ways to fix nerve injuries to see which method helps people heal better.

  Recruiting at 8 sites Auxilium Biotechnologies · San Diego, California and 7 other locations · NCT06529835

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.