How egg-based and cell-based flu vaccines compare over time
Official title: Impact of Egg-Based and Cell-Based Vaccine Platforms on Immune Responses to Repeated Influenza Vaccination
Run by University of Missouri-Columbia · NCT07910266 · Data updated 2026-11-12
This study tests whether using egg-based or cell-based flu vaccines, alone or in sequence, changes the immune response to future flu shots in adults.
Quick facts
| Phase | Phase 4 |
|---|---|
| Study type | Interventional |
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 220 (estimated) |
| Sponsor | University of Missouri-Columbia Academic / other |
| Locations | 1 site (Columbia, Missouri) |
| Status | Recruiting |
| Started | October 2026 |
| Main results expected | February 2027 |
| Study ends | September 2027 |
| Registry record updated | November 2, 2026 |
| Trial ID | NCT07910266 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults 18 years or older who plan to receive a flu vaccine this year or are willing to be randomized to egg-based or cell-based vaccines and to a second vaccination about 3 months later.
✕Probably not a fit
Individuals who do not respond to vaccines or who do not participate in the second vaccination may see limited benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Participants receive one of four vaccine sequences (egg-egg, egg-cell, cell-cell, cell-egg) and have blood samples collected up to eight times during the flu season to track immune responses. The trial will help determine if prior vaccine type or switching platforms affects antibody levels and immune cells against various flu strains. It is a randomized, interventional study conducted at the University of Missouri System.
Why it matters
Potential benefit: If successful, the trial could guide personalized flu vaccination strategies to optimize immune protection.
How similar studies have gone: Prior flu vaccine platform studies exist, but this specific combination and time-course approach is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Did NOT receive a flu shot last year * Planning to get flu shot this year; * 18 years of age or older; * English speaking * Willing to be randomized to receive either FDA-approved cell-based or egg-based flu vaccination * Willing to get a second flu shot about 3 months after the first one Exclusion Criteria: * Received a flu shot last year * Less than 18 years old * Not willing to be directed to get a certain type of vaccination * Not willing to get a flu vaccination or a second vaccination during the study period * Does not speak English * History of severe allergic reaction (e.g., anaphylaxis) following a previous influenza vaccine or to a component of the study vaccine. * Have a history of Guillain-Barré Syndrome within 6 weeks of a previous influenza vaccination. * Women who are pregnant or may be pregnant will not receive the second study vaccination
Where it's running
-
University of Missouri Systems
Columbia, Missouri, United States Recruiting
Study contacts
- Principal investigator: Xiu-Feng Wan, PhD — University of Missouri Systems
- Study coordinator: Anna Zakrzewicz, PhD
- Email: annazakrzewicz@umsystem.edu
- Phone: 573-882-3202
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.