Genome editing testing in animal models to inform future human therapies
Official title: Genome Editing and Biological Effects Testing: Somatic Cell Gene Editing Testing
Funded at University of Missouri-Columbia · NIH-11393742 · Data updated 2026-11-12
A NIH-supported project develops large-animal models and testing protocols to study genome editing therapies that could one day help people with genetic conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Missouri-Columbia NIH-funded |
| Lab location | 1 site (Columbia, United States) |
| Project start | September 12, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $817,794 |
| NIH project number | 5U42OD035738-04 |
| Project ID | NIH-11393742 on NIH RePORTER |
Who could benefit from this research
✓Could help
Not applicable to patient enrollment—focus is on animal models and preclinical testing to inform future human trials.
✕Less likely to help
No direct patient participation in this core facility; benefits are anticipated through future therapies rather than current participation.
What this research studies
This grant funds a center that creates swine models carrying human gene targets to study somatic cell genome editing. It will develop standardized procedures, preserve data, and coordinate researchers to evaluate safety and effectiveness of potential therapies in large animals. The aim is to translate basic genome editing science into clinical applications while ensuring rigorous testing and clear communication with collaborators.
Why it matters
Potential benefit: If successful, this work could accelerate the safe development of genome editing treatments for human diseases.
How similar studies have gone: Other preclinical genome editing programs have demonstrated translational potential through large-animal testing and procedural standardization.
Where this research is happening
-
University of Missouri-Columbia
Columbia, United States Active
Researchers
- Principal investigator: Green, Jonathan a — University of Missouri-Columbia
- Study coordinator: Green, Jonathan a
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.