How shorter sleep changes blood pressure responses
Official title: Impact of Sleep Restriction on Blood Pressure Reactivity
Run by University of Missouri-Columbia · NCT07489417 · Data updated 2026-11-12
We will test whether shorter nightly sleep changes blood pressure responses in healthy 18–45-year-olds who are either normal weight or have obesity.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 45 Years |
| Sex | All |
| Enrollment | 45 (estimated) |
| Sponsor | University of Missouri-Columbia Academic / other |
| Locations | 1 site (Columbia, Missouri) |
| Status | Recruiting |
| Started | March 4, 2026 |
| Main results expected | August 2027 |
| Study ends | August 2027 |
| Registry record updated | July 28, 2026 |
| Trial ID | NCT07489417 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are healthy non-smoking adults 18–45 years old, premenopausal if female, who habitually sleep 7–9 hours and have either BMI <25 kg/m² or ≥30 kg/m².
✕Probably not a fit
People with hypertension, significant medical conditions, current medications that affect sleep or cardiovascular function, pregnancy, breastfeeding, nicotine use, irregular sleep, or diagnosed sleep disorders like sleep apnea are unlikely to benefit or be eligible.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Healthy men and premenopausal women aged 18–45 who report habitual 7–9 hours of sleep and meet BMI criteria for either normal weight or obesity will be enrolled. Participants undergo sleep restriction as the intervention with physiological monitoring to measure blood pressure reactivity and cardiovascular responses. People taking medications or with medical conditions affecting sleep or cardiovascular function are excluded to isolate the effect of sleep duration. All visits and sleep procedures are conducted on-site at the University of Missouri–Columbia.
Why it matters
Potential benefit: If successful, the results could show that shortened sleep directly increases blood pressure responses and help shape sleep recommendations to reduce cardiovascular risk.
How similar studies have gone: Observational studies have linked short sleep to higher blood pressure, but controlled sleep-restriction intervention data in healthy adults are limited, so this work builds on suggestive prior findings rather than established interventions.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Healthy adult men and women * 18-45 years of age * BMI \< 25 kg/m² (normal weight group) or ≥ 30 kg/m² (obesity group) * Non-pregnant, non-breastfeeding, and non-nicotine users * Self-reported history of normal sleep duration (7-9 hours/night) and bedtime prior to midnight * Premenopausal Exclusion Criteria: * No acute or chronic conditions * Taking no medications known to affect sleep, autonomic, metabolic, or cardiovascular function * Self-reported history of irregular sleep * Self-reported history of hepatic, renal, pulmonary, cardiovascular, or neurological disease, stroke or neurovascular disease, bleeding/clotting disorders, sleep apnea or other sleep disorders, diabetes, history of alcoholism or substance abuse, major cardiovascular event or surgical procedure within the past three months, or hypertension
Where it's running
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University of Missouri
Columbia, Missouri, United States Recruiting
Study contacts
- Study coordinator: Jacqueline Limberg
- Email: limberglab@missouri.edu
- Phone: 1-573-882-2544
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.