How shorter sleep changes blood pressure responses
Impact of Sleep Restriction on Blood Pressure Reactivity
We will test whether shorter nightly sleep changes blood pressure responses in healthy 18–45-year-olds who are either normal weight or have obesity.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 45 (estimated) |
| Ages | 18 Years to 45 Years |
| Sex | All |
| Sponsor | University of Missouri-Columbia Academic / other |
| Locations | 1 site (Columbia, Missouri) |
| Trial ID | NCT07489417 on ClinicalTrials.gov |
What this trial studies
Healthy men and premenopausal women aged 18–45 who report habitual 7–9 hours of sleep and meet BMI criteria for either normal weight or obesity will be enrolled. Participants undergo sleep restriction as the intervention with physiological monitoring to measure blood pressure reactivity and cardiovascular responses. People taking medications or with medical conditions affecting sleep or cardiovascular function are excluded to isolate the effect of sleep duration. All visits and sleep procedures are conducted on-site at the University of Missouri–Columbia.
Who should consider this trial
Good fit: Ideal candidates are healthy non-smoking adults 18–45 years old, premenopausal if female, who habitually sleep 7–9 hours and have either BMI <25 kg/m² or ≥30 kg/m².
Not a fit: People with hypertension, significant medical conditions, current medications that affect sleep or cardiovascular function, pregnancy, breastfeeding, nicotine use, irregular sleep, or diagnosed sleep disorders like sleep apnea are unlikely to benefit or be eligible.
Why it matters
Potential benefit: If successful, the results could show that shortened sleep directly increases blood pressure responses and help shape sleep recommendations to reduce cardiovascular risk.
How similar studies have performed: Observational studies have linked short sleep to higher blood pressure, but controlled sleep-restriction intervention data in healthy adults are limited, so this work builds on suggestive prior findings rather than established interventions.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Healthy adult men and women * 18-45 years of age * BMI \< 25 kg/m² (normal weight group) or ≥ 30 kg/m² (obesity group) * Non-pregnant, non-breastfeeding, and non-nicotine users * Self-reported history of normal sleep duration (7-9 hours/night) and bedtime prior to midnight * Premenopausal Exclusion Criteria: * No acute or chronic conditions * Taking no medications known to affect sleep, autonomic, metabolic, or cardiovascular function * Self-reported history of irregular sleep * Self-reported history of hepatic, renal, pulmonary, cardiovascular, or neurological disease, stroke or neurovascular disease, bleeding/clotting disorders, sleep apnea or other sleep disorders, diabetes, history of alcoholism or substance abuse, major cardiovascular event or surgical procedure within the past three months, or hypertension
Where this trial is running
Columbia, Missouri
- University of Missouri — Columbia, Missouri, United States (Recruiting)
Study contacts
- Study coordinator: Jacqueline Limberg
- Email: limberglab@missouri.edu
- Phone: 1-573-882-2544
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.