Dual filament control of heart power and blood flow
Official title: Dual filament control of myocardial power and hemodynamics
Funded at University of Missouri-Columbia · NIH-11393835 · Data updated 2026-11-12
A team at the University of Missouri-Columbia is studying how heart muscle proteins control how hard the heart pumps, with aims to guide new therapies for heart failure.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Missouri-Columbia NIH-funded |
| Lab location | 1 site (Columbia, United States) |
| Project start | August 25, 2020 |
| Project end | May 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $638,907 |
| NIH project number | 5R01HL148785-06 |
| Project ID | NIH-11393835 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with heart failure or cardiomyopathy may indirectly benefit if findings translate into new therapies.
✕Less likely to help
Patients without heart disease are unlikely to gain direct benefit from this basic mechanistic study.
What this research studies
This project looks at how tiny filaments inside heart cells respond to load and influence the heart’s power output. Researchers will use biochemical tests, biophysical methods, and genetically modified models, then combine results with computer simulations to predict how small changes at the cellular level affect whole-heart function. The goal is to uncover mechanisms that could be targeted by future drugs to improve heart performance in people with heart failure.
Why it matters
Potential benefit: If successful, the work could point to new drug targets that help the heart pump more efficiently in patients with heart failure.
How similar studies have gone: Previous work has shown links between myofilament regulation and heart muscle power, supporting the potential for meaningful advances.
Where this research is happening
-
University of Missouri-Columbia
Columbia, United States Active
Researchers
- Principal investigator: Mcdonald, Kerry S — University of Missouri-Columbia
- Study coordinator: Mcdonald, Kerry S
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.