Understanding how dietary fiber shapes gut microbes through multi-omics
Official title: Integration of omics data to understand dietary fiber's effects
Funded at University of Missouri-Columbia · NIH-11438013 · Data updated 2026-11-12
A small research project will combine gut bacteria data and other biological information to learn how fiber in the diet changes health-related pathways in people.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Missouri-Columbia NIH-funded |
| Lab location | 1 site (Columbia, United States) |
| Project start | September 3, 2026 |
| Project end | August 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $231,868 |
| NIH project number | 1R03HL187212-01 |
| Project ID | NIH-11438013 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with overweight or obesity who participated in prior fiber-related studies and had colonoscopy or dietary interventions.
✕Less likely to help
Individuals without obesity or metabolic concerns or those not represented in the analyzed datasets may see limited immediate relevance.
What this research studies
This project analyzes existing multi-omics data from two human studies to see how fiber intake influences the gut microbiome and host biology. Researchers will use advanced sequencing and computational methods to link microbial changes with metabolic signals after fiber consumption. The goal is to uncover mechanisms by which fiber may affect conditions like obesity and metabolic syndrome, using real patient data. The study advances knowledge by integrating different types of biological information to paint a fuller picture of fiber’s effects on health.
Why it matters
Potential benefit: If successful, findings could guide personalized dietary fiber recommendations to improve metabolic health.
How similar studies have gone: Previous research has shown that fiber and gut microbes interact, and multi-omics approaches are increasingly used to understand these effects.
Where this research is happening
-
University of Missouri-Columbia
Columbia, United States Active
Researchers
- Principal investigator: Anguah, Katherene O — University of Missouri-Columbia
- Study coordinator: Anguah, Katherene O
Related research
Other NIH-funded projects on the same topics.
-
Boosting immune response to fight cancer
This study is exploring a new way to help your immune system better fight cancer by tweaking certain cells in your body, and it aims to improve treatment for people with advanced cancer.
-
Interface between immune cells and scarring in the eye
This grant looks at how immune cells influence scar formation in the cornea after injury and how this affects vision.
-
Understanding cell-cleanup problems in C9ORF72-related ALS/FTD
Researchers are studying why the body's cell-cleanup systems fail in a genetic form of ALS/FTD to pave the way for better treatments.
-
Molecular clues to endometriosis-related infertility
This grant explores how molecular changes in endometriosis contribute to infertility, with the aim of finding better ways to diagnose and treat the condition.
-
A universal Shigella vaccine using SAVE to protect people of all ages
A new vaccine approach called SAVE aims to prevent Shigella-related dysentery across all ages, including children and adults, by targeting conserved bacterial components.
-
Biomarkers that predict osteoarthritis risk in people at higher risk
A long-term study will look for protein markers in body fluids that could predict who will develop knee osteoarthritis before symptoms appear.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.