Examining how sex and obesity affect blood vessel responses to low oxygen

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This project investigates the mechanisms behind sex differences in hypoxic vasodilation, particularly focusing on the role of the sympathetic nervous system and the impact of obesity. It aims to understand how women may respond differently to low oxygen levels compared to men, especially in the context of obesity, which is prevalent among patients with sleep apnea. By exploring these mechanisms, the study hopes to enhance the effectiveness of existing therapies and pave the way for new treatment options for cardiovascular diseases linked to sleep apnea.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* BMI \>18 kg/m2

Exclusion Criteria:

* Pregnancy, breastfeeding
* Diagnosed sleep apnea or AHI \>10 events/hr
* Current smoking/Nicotine use
* Increased risk of bleeding, pro-coagulant disorders, clotting disorders, anticoagulation therapy
* Nerve/neurologic disease
* Cardiovascular, hepatic, renal, respiratory disease
* Blood pressure ≥140/90 mmHg
* Diabetes, Polycystic ovarian syndrome
* Communication barriers
* Prescription medications, Sensitivity to lidocaine

Where it's running

• University of Missouri
  Columbia, Missouri, United States Recruiting

Study contacts

• Principal investigator: Jacqueline Limberg, Ph.D. — University of Missouri-Columbia
• Study coordinator: Jacqueline K Limberg, Ph.D.
• Email: limbergj@missouri.edu
• Phone: 5738822544

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.