Examining how sex and obesity affect blood vessel responses to low oxygen
Sex Disparities in Hypoxic Vasodilation and Impact of Obesity
EARLY_PHASE1 · University of Missouri-Columbia · NCT05219799
This study is testing how being male or female and having obesity affects how blood vessels respond to low oxygen levels, especially in people with sleep apnea, to find better treatments for heart-related issues.
Quick facts
| Phase | EARLY_PHASE1 |
|---|---|
| Study type | Interventional |
| Enrollment | 72 (estimated) |
| Ages | 18 Years to 45 Years |
| Sex | All |
| Sponsor | University of Missouri-Columbia (other) |
| Locations | 1 site (Columbia, Missouri) |
| Trial ID | NCT05219799 on ClinicalTrials.gov |
What this trial studies
This project investigates the mechanisms behind sex differences in hypoxic vasodilation, particularly focusing on the role of the sympathetic nervous system and the impact of obesity. It aims to understand how women may respond differently to low oxygen levels compared to men, especially in the context of obesity, which is prevalent among patients with sleep apnea. By exploring these mechanisms, the study hopes to enhance the effectiveness of existing therapies and pave the way for new treatment options for cardiovascular diseases linked to sleep apnea.
Who should consider this trial
Good fit: Ideal candidates are individuals with a BMI greater than 18 kg/m2 who do not have sleep apnea or related conditions.
Not a fit: Patients who are pregnant, breastfeeding, or have significant cardiovascular or other systemic diseases may not benefit from this study.
Why it matters
Potential benefit: If successful, this research could lead to improved therapies for women with obesity-related cardiovascular issues.
How similar studies have performed: While studies on sex differences in cardiovascular responses exist, this specific focus on hypoxic vasodilation and obesity is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * BMI \>18 kg/m2 Exclusion Criteria: * Pregnancy, breastfeeding * Diagnosed sleep apnea or AHI \>10 events/hr * Current smoking/Nicotine use * Increased risk of bleeding, pro-coagulant disorders, clotting disorders, anticoagulation therapy * Nerve/neurologic disease * Cardiovascular, hepatic, renal, respiratory disease * Blood pressure ≥140/90 mmHg * Diabetes, Polycystic ovarian syndrome * Communication barriers * Prescription medications, Sensitivity to lidocaine
Where this trial is running
Columbia, Missouri
- University of Missouri — Columbia, Missouri, United States (RECRUITING)
Study contacts
- Principal investigator: Jacqueline Limberg, Ph.D. — University of Missouri-Columbia
- Study coordinator: Jacqueline K Limberg, Ph.D.
- Email: limbergj@missouri.edu
- Phone: 5738822544
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Obesity, Vasodilation, Healthy