Understanding how growth hormone affects insulin-producing cells in people with obesity

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to investigate the response of beta-cells, which produce insulin in the pancreas, to growth hormone in individuals with a family history of type 2 diabetes. Conducted at the University of Missouri, the research focuses on participants aged 18 to 45 who are obese but do not have diabetes. By comparing those with a family history of type 2 diabetes to a control group without such a history, the study seeks to enhance understanding of the relationship between growth hormone and the risk of developing gestational and type 2 diabetes.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* 18 to 59 years old
* body mass index ≥30.0 kg/m2 and \<45.0 kg/m2

Additional, group-specific inclusion criteria:

* Family history of type 2 diabetes: first degree relative with type 2 diabetes
* Control group: no family history of type 2 diabetes

Exclusion Criteria:

* Pregnant, planning to become pregnant during the study, or breastfeeding
* Current diagnosis or history of type 1 or type 2 diabetes
* Use of medications that can impact the study outcomes (e.g., GLP-1 receptor agonists)
* History of bariatric surgery
* Known, uncontrolled hypothyroidism
* History of intracranial hypertension, including papilledema, or a condition that increases the risk of developing intracranial hypertension, such as Turner Syndrome, Prader-Willi Syndrome, or renal impairment
* Current cancer or cancer that has been in remission less than 5 years
* First degree relative with type 1 diabetes diagnosis
* Evidence of significant anemia or significant end organ dysfunction (e.g., liver, kidney, heart disease)
* Alcohol use disorder, use of controlled substances, or smoking \>2 cigarettes per day
* Greater than 3% weight loss within three months of screening or engaged in regular (≥3 days per week), continuous moderate- or high-intensity exercise of ≥30 min duration
* Mentally disabled persons, prisoners, and persons with inability to grant voluntary informed consent

Where it's running

• University of Missouri School of Medicine
  Columbia, Missouri, United States Recruiting

Study contacts

• Principal investigator: Bettina Mittendorfer, PhD — University of Missouri-Columbia
• Study coordinator: Amanda Heider
• Email: ahmc4@health.missouri.edu
• Phone: 573-884-6852

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.