Understanding how growth hormone affects insulin-producing cells in people with obesity
Growth Hormone Resistance of Beta-cells in People With a Family History of Type 2 Diabetes
This study is trying to see how growth hormone affects insulin-producing cells in obese people aged 18 to 45 who have a family history of type 2 diabetes compared to those who don’t.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 30 (estimated) |
| Ages | 18 Years to 59 Years |
| Sex | All |
| Sponsor | University of Missouri-Columbia Academic / other |
| Locations | 1 site (Columbia, Missouri) |
| Trial ID | NCT06571500 on ClinicalTrials.gov |
What this trial studies
This observational study aims to investigate the response of beta-cells, which produce insulin in the pancreas, to growth hormone in individuals with a family history of type 2 diabetes. Conducted at the University of Missouri, the research focuses on participants aged 18 to 45 who are obese but do not have diabetes. By comparing those with a family history of type 2 diabetes to a control group without such a history, the study seeks to enhance understanding of the relationship between growth hormone and the risk of developing gestational and type 2 diabetes.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 to 45 with a body mass index between 30.0 and 45.0 kg/m2 and a family history of type 2 diabetes.
Not a fit: Patients who are pregnant, have a current diagnosis of diabetes, or have certain medical conditions that could interfere with the study will not benefit.
Why it matters
Potential benefit: If successful, this study could provide insights into the mechanisms of diabetes development and lead to better prevention strategies for at-risk individuals.
How similar studies have performed: While this study explores a specific aspect of beta-cell function in relation to growth hormone, similar studies have shown promise in understanding diabetes risk factors, making this approach both relevant and potentially impactful.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * 18 to 59 years old * body mass index ≥30.0 kg/m2 and \<45.0 kg/m2 Additional, group-specific inclusion criteria: * Family history of type 2 diabetes: first degree relative with type 2 diabetes * Control group: no family history of type 2 diabetes Exclusion Criteria: * Pregnant, planning to become pregnant during the study, or breastfeeding * Current diagnosis or history of type 1 or type 2 diabetes * Use of medications that can impact the study outcomes (e.g., GLP-1 receptor agonists) * History of bariatric surgery * Known, uncontrolled hypothyroidism * History of intracranial hypertension, including papilledema, or a condition that increases the risk of developing intracranial hypertension, such as Turner Syndrome, Prader-Willi Syndrome, or renal impairment * Current cancer or cancer that has been in remission less than 5 years * First degree relative with type 1 diabetes diagnosis * Evidence of significant anemia or significant end organ dysfunction (e.g., liver, kidney, heart disease) * Alcohol use disorder, use of controlled substances, or smoking \>2 cigarettes per day * Greater than 3% weight loss within three months of screening or engaged in regular (≥3 days per week), continuous moderate- or high-intensity exercise of ≥30 min duration * Mentally disabled persons, prisoners, and persons with inability to grant voluntary informed consent
Where this trial is running
Columbia, Missouri
- University of Missouri School of Medicine — Columbia, Missouri, United States (Recruiting)
Study contacts
- Principal investigator: Bettina Mittendorfer, PhD — University of Missouri-Columbia
- Study coordinator: Amanda Heider
- Email: ahmc4@health.missouri.edu
- Phone: 573-884-6852
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.