Registry for 3D talus replacement in patients with avascular necrosis
Official title: Talus Replacement Registry
Run by University of Missouri-Columbia · NCT03965143 · Data updated 2026-11-12
This study is testing a new 3D talus replacement procedure to see if it helps people with avascular necrosis of the talus recover better and improve their foot function.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 50 (estimated) |
| Sponsor | University of Missouri-Columbia Academic / other |
| Locations | 1 site (Columbia, Missouri) |
| Status | Recruiting |
| Started | January 1, 2020 |
| Main results expected | May 1, 2027 |
| Study ends | May 1, 2027 |
| Registry record updated | April 28, 2026 |
| Trial ID | NCT03965143 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults aged 18 and older who require total talus replacement due to avascular necrosis.
✕Probably not a fit
Patients with active infections, those unable to consent, or individuals whose condition does not qualify for total talus replacement may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study focuses on patients with avascular necrosis of the talus who undergo a 3D talar augmentation procedure. Participants will return for follow-up visits at specified intervals to assess their recovery through X-rays, walking speed evaluations, and various surveys measuring pain, satisfaction, and overall outcomes. The aim is to gather data on the effectiveness of this innovative approach in restoring foot function and mobility. The study seeks to provide valuable insights into the long-term benefits and potential complications associated with this treatment.
Why it matters
Potential benefit: If successful, this study could lead to improved treatment options for patients suffering from avascular necrosis of the talus, enhancing their mobility and quality of life.
How similar studies have gone: While the use of 3D printing in orthopedic procedures is gaining traction, this specific approach to talus replacement is relatively novel and requires further validation.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Subjects age 18 years or above at time of screening 2. Condition satisfies requirement for total talus replacement 3. Able to consent and participate in the study 4. No previous history of septic arthritis involving the hindfoot/midfoot 5. Previous ability to ambulate Exclusion Criteria: 1. Active infection, sepsis, osteomyelitis or history of septic arthritis involving the hindfoot/midfoot 2. Unable to consent or participate in the study secondary to mental status 3. Condition does not qualify for a total talus replacement 4. Patients who are pregnant or imprisoned 5. Planned relocation or unable to return for required follow-up visits
Where it's running
-
University of Missouri
Columbia, Missouri, United States Recruiting
Study contacts
- Principal investigator: Kyle M Schweser, MD — Assistant Professor Orthopaedic Trauma/Foot and Ankle
- Study coordinator: Vicki L Jones, M Ed
- Email: jonesvicki@health.missouri.edu
- Phone: 5738827583
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Post Approval Study of a Custom Talus Spacer for Ankle Avascular Necrosis
This study is testing a custom-made device for people with ankle avascular necrosis to see if it can help reduce pain and improve movement.
-
How egg-based and cell-based flu vaccines compare over time
This study tests whether using egg-based or cell-based flu vaccines, alone or in sequence, changes the immune response to future flu shots in adults.
-
Sirolimus for ApoE4 Carriers: Testing Brain Blood Flow in Women 45-65
Researchers will test whether sirolimus can improve brain blood flow in healthy ApoE4-positive women ages 45 to 65 compared with a placebo.
-
Beta3-adrenergic Receptors and Vascular Function in Aging Women
This trial tests whether activating beta3-adrenergic receptors can improve blood vessel function in aging women undergoing menopause.
-
Talar Osteochondral Lesions in Pilon Fractures: Nano-Arthroscopy During External Fixation
This study tests whether tiny ankle arthroscopy during external fixation can find talar cartilage lesions in adults with pilon fractures and help plan future treatment.
-
How shorter sleep changes blood pressure responses
We will test whether shorter nightly sleep changes blood pressure responses in healthy 18–45-year-olds who are either normal weight or have obesity.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.