Understanding blood flow changes in aging women
Early Neurovascular Adaptations in Aging Women
This study is testing how different treatments affect blood flow in women aged 18 to 55 to better understand changes in their cardiovascular health as they age.
Quick facts
| Phase | Early Phase 1 |
|---|---|
| Study type | Interventional |
| Enrollment | 64 (estimated) |
| Ages | 18 Years to 70 Years |
| Sex | Female |
| Sponsor | University of Missouri-Columbia Academic / other |
| Locations | 1 site (Columbia, Missouri) |
| Trial ID | NCT06520982 on ClinicalTrials.gov |
What this trial studies
This study aims to investigate early neurovascular adaptations in women aged 18 to 55, focusing on how the sympathetic nervous system influences blood flow as they age. Participants will receive various interventions, including norepinephrine, isoproterenol, acetylcholine, nitroprusside, and estrogen, to assess their effects on vascular function. The research seeks to enhance knowledge about the physiological changes that occur in aging women, which may have implications for their cardiovascular health.
Who should consider this trial
Good fit: Ideal candidates for this study are women assigned female at birth, aged 18 to 55, who do not have significant health issues.
Not a fit: Patients who are assigned male at birth, pregnant, or have chronic diseases or significant health risks may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved understanding and management of cardiovascular health in aging women.
How similar studies have performed: While there is ongoing research in vascular adaptations, this specific focus on aging women and the sympathetic nervous system is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Assigned female at birth (AFAB) * 18-70 years of age Exclusion Criteria: * Assigned male at birth (AMAB) * Pregnancy, breastfeeding * Body mass index ≥30 kg/m2 * Taking medications known to affect metabolic, autonomic, and/or respiratory function * Oral hormonal contraception in last 6 month * History of hormone replacement therapy * History of hyster- or oophor-ectomy * Current smoking/Nicotine use * Increased risk of bleeding, pro-coagulant disorders, clotting disorders, anticoagulation therapy * Chronic disease * Blood pressure ≥140/90 mmHg * Communication barriers
Where this trial is running
Columbia, Missouri
- University of Missouri-Columbia — Columbia, Missouri, United States (Recruiting)
Study contacts
- Study coordinator: Jacqueline K Limberg
- Email: limbergj@missouri.edu
- Phone: 573-882-2420
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.