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Clinical trial Recruiting at 1 site Early Phase 1 Interventional Ages 18 to 70 Women only

Understanding blood flow changes in aging women

Official title: Early Neurovascular Adaptations in Aging Women

Run by University of Missouri-Columbia · NCT06520982 · Data updated 2026-11-12

This study is testing how different treatments affect blood flow in women aged 18 to 55 to better understand changes in their cardiovascular health as they age.

Quick facts

PhaseEarly Phase 1
Study typeInterventional
Ages18 Years to 70 Years
SexWomen only
Enrollment64 (estimated)
SponsorUniversity of Missouri-Columbia
Academic / other
Locations1 site (Columbia, Missouri)
StatusRecruiting
StartedSeptember 20, 2024
Main results expectedJune 30, 2027
Study endsJune 30, 2028
Registry record updatedNovember 26, 2025
Trial IDNCT06520982 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this study are women assigned female at birth, aged 18 to 55, who do not have significant health issues.

Probably not a fit

Patients who are assigned male at birth, pregnant, or have chronic diseases or significant health risks may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to investigate early neurovascular adaptations in women aged 18 to 55, focusing on how the sympathetic nervous system influences blood flow as they age. Participants will receive various interventions, including norepinephrine, isoproterenol, acetylcholine, nitroprusside, and estrogen, to assess their effects on vascular function. The research seeks to enhance knowledge about the physiological changes that occur in aging women, which may have implications for their cardiovascular health.

Why it matters

Potential benefit: If successful, this study could lead to improved understanding and management of cardiovascular health in aging women.

How similar studies have gone: While there is ongoing research in vascular adaptations, this specific focus on aging women and the sympathetic nervous system is relatively novel.

Who can join: the full rules

Show full inclusion / exclusion criteria 
Inclusion Criteria:

* Assigned female at birth (AFAB)
* 18-70 years of age

Exclusion Criteria:

* Assigned male at birth (AMAB)
* Pregnancy, breastfeeding
* Body mass index ≥30 kg/m2
* Taking medications known to affect metabolic, autonomic, and/or respiratory function
* Oral hormonal contraception in last 6 month
* History of hormone replacement therapy
* History of hyster- or oophor-ectomy
* Current smoking/Nicotine use
* Increased risk of bleeding, pro-coagulant disorders, clotting disorders, anticoagulation therapy
* Chronic disease
* Blood pressure ≥140/90 mmHg
* Communication barriers

Where it's running

  • University of Missouri-Columbia
    Columbia, Missouri, United States     Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
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Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.