Condition

Amyotrophic Lateral Sclerosis (ALS) clinical trials and research

• 36Clinical trials
• 11NIH research projects
• 22Countries

Newest Amyotrophic Lateral Sclerosis (ALS) clinical trials

All recruiting trials (36)

• Early detection of respiratory impairment in ALS using breathing, MRI, and blood markers

  This study tests whether breathing patterns, MRI changes in the brainstem and spinal cord, and blood markers can reveal early ALS signs, especially in people with genetic risk or early symptoms.

  Recruiting Thomas Jefferson University · Philadelphia, Pennsylvania · NCT07844590

• Plasmapheresis for ALS with anti-NRIP autoantibody

  This study tests whether a few plasmapheresis sessions can help people with ALS who have anti-NRIP autoantibody by keeping the antibody levels low.

  Recruiting National Taiwan University Hospital · Taipei City, Taipei · NCT07726563

• Implanted brain interface to let people with severe paralysis control assistive devices

  It will try an implanted brain interface that records and stimulates brain signals so adults with severe paralysis can control assistive devices and receive sensory feedback.

  Recruiting Johns Hopkins University · Baltimore, Maryland · NCT07521930

• Do video recordings of multidisciplinary clinics help ALS patients and caregivers?

  This study tests whether providing a video recording of ALS multidisciplinary clinic visits, in addition to written notes, helps patients and their caregivers manage information and feel better about care.

  Recruiting Trustees of Dartmouth College · Scottsdale, Arizona and 6 other locations · NCT07454733

• Measuring Hsp90 levels in the human brain

  This trial tests whether a PET tracer called [11C]HSP990 can measure Hsp90 levels in the brains of healthy adults and people with Parkinson's disease, Alzheimer's disease, or ALS.

  Recruiting Universitaire Ziekenhuizen KU Leuven · Leuven, Vlaam-Brabant · NCT07380204

• NB-4746 in people with ALS

  This trial tests NB-4746 against placebo to see if it is safe and may help people with ALS.

  Recruiting at 12 sites Phase 1/2 Nura Bio · Concord, New South Wales and 11 other locations · NCT07369076

• Single-cell profiling of peripheral nerves to find blood and skin biomarkers and new targets for ALS

  This project will try to find proteins in peripheral nerves, blood, and skin that signal early ALS in adults with recent-onset disease, people with genetic risk, and healthy controls.

  Recruiting at 4 sites Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta · Monserrato, California and 3 other locations · NCT07268833

• Daily lung insufflation training to help protect breathing in ALS

  This project will test whether using a home LIC Trainer twice daily can slow breathing decline and delay the need for ventilatory support in people with ALS.

  Recruiting National Center of Neurology and Psychiatry, Japan · Kodaira, Tokyo · NCT07257302

• Healing ALS Registry (HAROS) for people with ALS, MND, and PLS

  This fully remote registry asks people with ALS, MND, or PLS to enter monthly health, treatment, and lifestyle information to try to see which therapies and education relate to better physical outcomes.

  Recruiting Healing Advocates Registry and Ministry · Park City, Utah · NCT07233148

• Finding early biological signs of ALS

  This project will test whether a molecular fingerprint in spinal fluid can detect ALS early in people with ALS gene mutations, in early ALS patients, and in matched controls.

  Recruiting Institut National de la Santé Et de la Recherche Médicale, France · Tours, France · NCT07213440

• Using ultra-high field and metabolic MRI to understand resilience and degeneration in the aging and diseased brain

  This project will try advanced 3T and 7T MRI scans, including sodium and phosphorus imaging, to see if metabolic and connectivity changes explain resilience and degeneration in adults with MS, NMOSD, MOGAD, Alzheimer’s, Parkinson’s, or healthy aging.

  Recruiting Assistance Publique Hopitaux De Marseille · Marseille · NCT07202494

• Electrical stimulation to reduce facial pain and improve jaw movement and chewing in people with motor neuron disease

  This trial will try one 30-minute session of non-invasive facial electrical stimulation to see if it reduces jaw and facial pain and improves chewing and jaw movement for people with ALS or PLS.

  Recruiting Nova Southeastern University · Davie, Florida · NCT07187388

• PHENOGENE-1A (cromolyn) treatment for people with mild to moderate ALS

  This study will test whether inhaled PHENOGENE-1A (cromolyn) helps people with mild to moderate ALS maintain function and lung capacity over 24 weeks while they continue riluzole.

  Recruiting at 22 sites Phase 2 PhenoNet, Inc. · Scottsdale, Arizona and 21 other locations · NCT07142291

• Robotically implanted Neuralink N1 brain-computer interface to control external devices

  This study will test whether a robotically implanted Neuralink N1 brain-computer interface can safely help people with high spinal cord injuries or ALS control computers and other external devices.

  Recruiting at 2 sites Neuralink Corp · London, Greater London and 1 other locations · NCT07127172

• XS228CN motor neuron progenitor cell therapy for ALS: safety, tolerability and early efficacy

  This study will test whether XS228CN iPSC-derived motor neuron progenitor cells are safe and tolerable in adults with definite or probable ALS who have preserved lung function.

  Recruiting Phase 1 XellSmart Bio-Pharmaceutical (Suzhou) Co., Ltd. · Beijing, Beijing Municipality · NCT07118319

• Early Non-Invasive Ventilation in ALS

  This study tests whether starting non-invasive ventilation earlier in adults with ALS can help improve breathing and quality of life.

  Recruiting at 3 sites Phase 2 University of Pennsylvania · Hershey, Pennsylvania and 2 other locations · NCT07071935

• Usnoflast Neuromuscular Investigation for ALS treatment efficacy

  This study tests Usnoflast at different doses against placebo to see if it helps adults with ALS.

  Recruiting at 25 sites Phase 2 Zydus Therapeutics Inc. · La Jolla, California and 48 other locations · NCT07023835

• Intestinal microbiome transplant for people with ALS

  This 24-week treatment tests whether taking MTP-101C capsules after antibiotic conditioning and bowel prep can change the gut microbiome and a blood marker in people with fast-progressing ALS who can swallow pills.

  Recruiting Phase 1/2 Duke University · Durham, North Carolina · NCT07017946

• Robotically implanted brain chip to help control external devices

  This tests a wireless, rechargeable brain implant (Neuralink N1) and a robot surgical system (R1) to help people with severe arm and hand paralysis control external devices.

  Recruiting Neuralink Corp · Abu Dhabi · NCT06992596

• Personalized genetic and biomarker approach for ALS

  This study is testing how genetic and biomarker information can help understand the differences in ALS for 200 newly diagnosed patients.

  Recruiting at 4 sites A.O.U. Città della Salute e della Scienza · Milan and 3 other locations · NCT06917924

• Using a new PET tracer to measure TDP-43 protein in dementia and ALS

  This study is testing a new imaging method to see if it can safely detect a specific protein linked to frontotemporal dementia and ALS in the brains of people with these conditions and healthy volunteers.

  Recruiting Early Phase 1 AC Immune SA · Amsterdam · NCT06891716

• High-calorie nutrition for ALS patients with PEG feeding

  This study is testing if a high-calorie diet can help ALS patients who are fed through a tube maintain their weight and live longer.

  Recruiting University of Ulm · Ulm, Baden-Wurttemberg · NCT06877143

• Evaluating VGN-R13 for treating ALS

  This study is testing a new gene therapy called VGN-R13 to see if it can safely help people with ALS feel better.

  Recruiting Early Phase 1 Tongji Hospital · Wuhan, Hubei · NCT06849609

• Examining how communication affects ALS patients and their caregivers

  This study is testing how different ways of talking can help ALS patients communicate better with their caregivers.

  Recruiting Penn State University · University Park, Pennsylvania · NCT06819124

• Identifying protein biomarkers in biofluids for neurodegenerative disorders

  This study is trying to find specific proteins in blood and other fluids that could help doctors diagnose and manage neurodegenerative diseases like Parkinson's and Alzheimer's earlier and better.

  Recruiting Neuromed IRCCS · Pozzilli, Italy · NCT06803784

• Improving nutritional status and frailty in patients with motor neuron disease using silkworm pupa powder

  This study is testing if adding silkworm pupa powder to the diets of people with motor neuron disease, like ALS, can help improve their nutrition, muscle strength, and overall health.

  Recruiting First People's Hospital of Hangzhou · Hangzhou, Zhejiang · NCT06765499

• HD-tDCS in ALS: a multicenter test of diaphragmatic motor cortex stimulation

  This trial tests whether high-definition transcranial direct current stimulation (HD-tDCS) can help people with ALS by targeting the diaphragmatic motor area to improve breathing and disease progression.

  Recruiting at 2 sites Phase 2/3 Universidade Federal do Rio Grande do Norte · Brasília, Federal District and 3 other locations · NCT06719947

• Robotically implanted brain-computer interface for controlling devices

  This study is testing a new brain implant and robot to see if they can help people with severe movement limitations control devices more easily.

  Recruiting Neuralink Corp · Toronto, Ontario · NCT06700304

• Improving motor function in ALS patients using pulse stimulation

  This study is testing if a new brain stimulation treatment can improve movement and daily function in people with ALS.

  Recruiting Parc de Salut Mar · Barcelona, Catalonia · NCT06681610

• Using regulatory T cells to treat neurodegenerative diseases

  This study is testing if injections of specially made immune cells can help people with neurodegenerative diseases like ALS, Alzheimer's, and Multiple System Atrophy feel better.

  Recruiting Phase 1 Novabio Therapeutics · Zhengzhou, Henan · NCT06671236

• Influence of Smell and Taste on Nutrition in ALS Patients

  This study tests whether olfactory and gustatory changes affect the nutrition of adults with ALS.

  Recruiting Centre Hospitalier Universitaire Dijon · Dijon · NCT06608004

• Testing a new drug for ALS caused by SOD1 gene mutations

  This study is testing a new drug for adults with ALS caused by SOD1 gene mutations to see if it's safe and how it affects their symptoms and certain markers in their blood and spinal fluid.

  Recruiting at 22 sites Phase 1/2 Regeneron Pharmaceuticals · Concord, New South Wales and 21 other locations · NCT06351592

• Evaluating the safety and tolerability of FB418 in healthy adults and elderly

  This study is testing how safe and well-tolerated a new drug called FB418 is in healthy adults and older people by giving them single and multiple doses.

  Recruiting Phase 1 1ST Biotherapeutics, Inc. · Seoul · NCT05995782

• MindEx multifocal cognitive brain‑machine interface for people with severe paralysis

  This trial will test the MindEx system, which uses four tiny implanted brain chips to let people with severe paralysis control a computer or tablet with their thoughts.

  Recruiting University of Texas Southwestern Medical Center · Dallas, Texas · NCT05936619

• Evaluating a new imaging biomarker for neuroinflammation in neurodegenerative diseases

  This study is testing a new imaging tool to see if it can help us understand brain inflammation in people with neurodegenerative diseases like ALS, Alzheimer’s, multiple sclerosis, and Parkinson’s, as well as in healthy volunteers.

  Recruiting at 3 sites Phase 1/2 Ashvattha Therapeutics, Inc. · San Francisco, California and 2 other locations · NCT05395624

• Evaluating retinal imaging for neurodegenerative diseases

  This study is testing if special eye scans can help spot early signs of neurodegenerative diseases like Alzheimer's and Parkinson's in people.

  Recruiting Duke University · Durham, North Carolina · NCT03233646

NIH-funded research (11)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Investigating how DNA damage and repair mechanisms are altered in ALS and frontotemporal dementia.

  This study is looking at how problems with DNA repair might contribute to conditions like ALS and frontotemporal dementia, and it’s testing ways to fix these issues in cells from patients to help develop new treatments.

  NIH research Methodist Hospital Research Institute · Houston, United States · NIH-9980670

• CNM-Au8 Expanded Access for ALS patients across the U.S.

  A wide-access program is testing CNM-Au8, a neuroprotective medicine, for people with ALS across all 50 states.

  NIH research New York University School of Medicine · New York, United States · NIH-11415221

• Access to CNM-Au8 for people with ALS

  This program offers people with ALS access to CNM-Au8, an experimental oral therapy that aims to protect motor neurons and support cellular energy.

  NIH research New York University School of Medicine · New York, United States · NIH-11405390

• Biomarker test for early ALS diagnosis using Nano-QuIC detection of misfolded TDP-43

  A new blood, spinal fluid, or nasal swab test using Nano-QuIC aims to detect misfolded TDP-43 early in people at risk for ALS to speed up diagnosis and treatment.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11358045

• Engineered regulatory immune cells to protect nerves in ALS

  Engineered regulatory immune cells (CAR Tregs) that seek out misfolded SOD1 and calm inflammation around motor neurons in people with ALS.

  NIH research Celdara Medical, LLC · Lebanon, United States · NIH-11181028

• Using engineered immune cells to treat ALS

  This study is exploring a new way to help people with ALS by using specially designed immune cells to target harmful proteins in the body, with the hope of reducing inflammation and slowing down the disease.

  NIH research Celdara Medical, LLC · Lebanon, United States · NIH-11128419

• Understanding ALS Risk in Workers with Certain Occupations

  This project is creating a group of people at higher risk for ALS to learn how their jobs and genes might lead to the disease.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11113782

• Investigating new treatments for frontotemporal dementia and ALS using gene editing

  This study is looking at ways to help people with frontotemporal dementia and ALS by using a special gene-editing tool to fix a harmful gene that causes these diseases.

  NIH research J. David Gladstone Institutes · San Francisco, United States · NIH-11089394

• Understanding motor neuron damage in ALS patients

  This study is looking into what causes damage to the nerves that control movement in people with ALS, using advanced imaging and brain analysis to better understand the connection between brain changes and the symptoms you experience, all with the goal of improving how we diagnose and understand the condition.

  NIH research Cedars-Sinai Medical Center · Los Angeles, United States · NIH-11055203

• Access to a new treatment for ALS using a neuroprotective drug.

  This study is looking for people with ALS to try a new drug called CNM-Au8® that might help protect their nerve cells and improve their energy, with the hope of slowing down the progression of the disease.

  NIH research Columbia University Health Sciences · New York, United States · NIH-10934384

• Understanding how work-related exposures and genetics affect ALS risk

  This study is looking for people who might be at a higher risk for ALS because of their jobs, especially those in production and metal work, to see how their work and genetics might affect their chances of developing the disease over time.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-10909768

Related topics

Quick answers

How many Amyotrophic Lateral Sclerosis (ALS) clinical trials are recruiting right now?

36, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 22 countries. The most sites are in United States (13 trials), Italy (4 trials), Germany (4 trials), Canada (4 trials), Poland (4 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1/2: 4, Phase 2: 3, Phase 1: 3, Early Phase 1: 2. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

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