Overcoming Neurogenic Inflammation to Help Recovery After Spinal Cord Injury
Official title: Overcoming Neurogenic “Meta-Inflammation” to Promote Recovery After Spinal Cord Injury
Funded at Ohio State University · NIH-11380635 · Data updated 2026-11-12
A long-term research project explores how spinal cord injury affects the body’s inflammation and metabolism, with the goal of improving health and recovery for adults with SCI.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project start | May 1, 2019 |
| Project end | April 30, 2027 |
| Funding year | 2026 |
| Award (this year) | $1,157,689 |
| NIH project number | 5R35NS111582-08 |
| Project ID | NIH-11380635 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with spinal cord injury who are at risk for immune or metabolic complications may benefit from the findings.
✕Less likely to help
Individuals without SCI or those not experiencing related immune/metabolic issues may not benefit.
What this research studies
This grant studies how spinal cord injury triggers immune and metabolic problems across multiple organs, not just movement. Researchers will look at how changes in nerve signaling after injury lead to immune dysfunction and organ-wide changes in metabolism. The work aims to identify mechanisms that could be targeted to restore balance in immune and metabolic processes and support overall recovery. It involves experiments that connect nervous system changes to body-wide health, with potential implications for preventing complications like infections, fatty liver, depression, and metabolic diseases.
Why it matters
Potential benefit: If successful, findings could lead to new strategies to prevent organ complications after SCI and improve both health and quality of life for patients.
How similar studies have gone: Previous data suggest immune and metabolic dysregulation after SCI is linked to worse outcomes, making this approach promising but still exploratory.
Where this research is happening
-
Ohio State University
Columbus, United States Active
Researchers
- Principal investigator: Popovich, Phillip G — Ohio State University
- Study coordinator: Popovich, Phillip G
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.