COSCINUS cohort and biocollection for spinal cord injury
Cohorte COSCINUS - Biocollection COhort in Spinal Cord Injury - Nantes Follow-Up Standardization
This project collects clinical information and blood, urine, and stool samples to see patterns and risk factors in people with spinal cord injury.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 105 (estimated) |
| Ages | 16 Years and up |
| Sex | All |
| Sponsor | Nantes University Hospital Academic / other |
| Locations | 1 site (Nantes, Loire-Atlantique) |
| Trial ID | NCT06734000 on ClinicalTrials.gov |
What this trial studies
COSCINUS is a standardized, longitudinal cohort and biocollection based at Nantes University Hospital that systematically records clinical, demographic, functional, and participation data for people with spinal cord injury. Biological samples (blood, urine, feces) are preserved to enable analyses of the microbiome and biomarkers related to metabolism, inflammation, immunity, and injury severity. Data and samples are collected prospectively at defined time points including the acute phase, admission to the PRM department, six months, discharge, and scheduled follow-up visits (1, 2, 3 years) with additional sampling during complications. The platform combines clinical, epidemiological, biostatistical, and IT expertise to support longitudinal analyses and future research collaborations.
Who should consider this trial
Good fit: People with a new spinal cord injury admitted in the initial phase of paraplegia or tetraplegia to the Neurological PRM department at Nantes University Hospital who are covered by social security are eligible to participate.
Not a fit: Patients who are not covered by social security or who are not treated at Nantes University Hospital are not eligible and therefore would not directly benefit from participation in this cohort.
Why it matters
Potential benefit: If successful, this cohort could improve understanding of complication risks and biological markers after spinal cord injury, supporting better prevention and personalized care.
How similar studies have performed: Other longitudinal cohorts and biobanks in spinal cord injury have yielded useful epidemiological and biomarker insights, and COSCINUS applies these established methods at a national-level scale.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * All individuals with spinal cord injury admitted to the neurological PRM department of the Nantes University Hospital at the initial phase of development of the paraplegia or tetraplegia could participate, regardless the clinical neurological status. Exclusion Criteria: * Patients not covered by social security.
Where this trial is running
Nantes, Loire-Atlantique
- Nantes University Hospital — Nantes, Loire-Atlantique, France (Recruiting)
Study contacts
- Study coordinator: Brigitte Perrouin Verbe
- Email: bp-prom-regl@chu-nantes.fr
- Phone: +33 2 53 48 28 35
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.