Spinal Direct Current Stimulation to Improve Breathing After Cervical Cord Injury
Official title: Spinal Direct Current Stimulation to Enhance Breathing Following Cervical Spinal Cord Injury
Funded at Ohio State University · NIH-11416964 · Data updated 2026-11-12
A non-invasive therapy using gentle electrical stimulation to help people with spinal cord injuries breathe better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project start | April 10, 2024 |
| Project end | March 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $249,000 |
| NIH project number | 4R00NS133388-03 |
| Project ID | NIH-11416964 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates would be individuals with cervical spinal cord injury who have respiratory impairment and could benefit from neuromodulatory therapies.
✕Less likely to help
Patients without respiratory dysfunction related to SCI or those unable to participate in non-invasive neuromodulation would be less likely to benefit.
What this research studies
This project tests a non-invasive, low-intensity electrical technique (tsDCS) to boost respiratory function in a rodent model of cervical spinal cord injury. The study builds on Dr. Rana’s experience in SCI neurobiology and respiratory control to explore how neuromodulation can enhance breathing after injury. The University of Florida environment and its Breathing Research and Therapeutics Center will support the work with experts in respiratory motor control and SCI rehabilitation.
Why it matters
Potential benefit: If successful, this approach could lead to new ways to improve breathing and reduce respiratory complications in people with SCI.
How similar studies have gone: Previous work in neuromodulation and respiratory control has shown potential for improving breathing, but translating to clinical benefit requires further study.
Where this research is happening
-
Ohio State University
Columbus, United States Active
Researchers
- Principal investigator: Rana, Sabhya — Ohio State University
- Study coordinator: Rana, Sabhya
Related research
Other NIH-funded projects on the same topics.
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Predicting and Preventing Chronic Aspiration After Traumatic Cervical Spinal Cord Injury
This project looks at swallowing problems and chronic aspiration in adults with traumatic neck spine injuries to find patterns that could prevent serious lung complications.
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Combining breathing therapies to help restore breathing after neck-level spinal cord injury
This project will see whether brief bursts of low oxygen combined with breathing exercises or exercise can help people with chronic neck spinal cord injuries breathe better.
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Transplanting Lab-Grown Human Neurons to Help cervical spinal cord injuries
Researchers are testing whether transplanting lab-made human neurons into the neck portion of the spinal cord can improve arm and hand function after injury.
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Neural repair for chronic incomplete cervical spinal cord injury with NgR blockade plus rehab
Aiming to help adults with long-standing incomplete cervical spinal cord injury improve movement and function by blocking a specific nerve signal pathway and adding targeted rehabilitation.
-
Using a mobile robot to help people with severe spinal cord injuries live more independently
This study is working on a friendly robot that can help people with tetraplegia do everyday tasks like bathing, dressing, and eating, making life a little easier and more independent while also supporting their emotional needs.
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Improving breathing recovery after cervical spinal cord injury
This study is looking at new ways to help people with cervical spinal cord injuries breathe better by combining special breathing exercises with short periods of low oxygen, aiming to boost their recovery and strengthen their breathing muscles.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.