NIH-funded research R01 grant

Corticospinal neurons and recovery of precise forelimb movement after spinal cord injury

Official title: The Role of Corticospinal Neurons in the Recovery of Dexterous Forelimb Function After Spinal Cord Injury

Funded at Weill Medical Coll of Cornell Univ · NIH-11628900 · Data updated 2026-11-12

This project studies how spine injuries change brain circuits and whether targeted rehabilitation helps restore precise forelimb movement.

More Spinal Cord Injury research and trials

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionWeill Medical Coll of Cornell Univ
NIH-funded
Lab location1 site (New York, United States)
Project startMay 4, 2024
Project endApril 30, 2029
Funding year2026
Award (this year)$462,328
NIH project number7R01NS136711-04
Project IDNIH-11628900 on NIH RePORTER

Who could benefit from this research

Could help

Ideal candidates are individuals with or at risk of spinal cord injury and who can participate in rehabilitation paradigms.

Less likely to help

Patients not able to participate in rehabilitation protocols or with injuries outside the corticospinal system may not benefit.

What this research studies

After a spinal cord injury, the brain’s control of the forelimb is altered, and rehabilitation may help rewire the circuits that control movement. The study will examine how rehabilitation influences remodeling of corticospinal neurons and whether these injured neurons can be incorporated into healthy motor networks. Researchers will use models that reveal how training shapes cortical maps and motor outputs. The goal is to identify rehabilitation strategies that best support functional recovery of dexterous forelimb use.

Why it matters

Potential benefit: If successful, the work could lead to better rehabilitation approaches that improve hand and arm function after spinal cord injury.

How similar studies have gone: Previous research suggests that rehabilitation can remodel brain motor maps and aid recovery, but the exact neuronal remodeling process remains under study.

Where this research is happening

  • Weill Medical Coll of Cornell Univ
    New York, United States
    Active

Researchers

  • Principal investigator: Hollis, Edmund R — Weill Medical Coll of Cornell Univ
  • Study coordinator: Hollis, Edmund R

Related research

Other NIH-funded projects on the same topics.

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.