Corticospinal neurons and recovery of precise forelimb movement after spinal cord injury
Official title: The Role of Corticospinal Neurons in the Recovery of Dexterous Forelimb Function After Spinal Cord Injury
Funded at Weill Medical Coll of Cornell Univ · NIH-11628900 · Data updated 2026-11-12
This project studies how spine injuries change brain circuits and whether targeted rehabilitation helps restore precise forelimb movement.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | May 4, 2024 |
| Project end | April 30, 2029 |
| Funding year | 2026 |
| Award (this year) | $462,328 |
| NIH project number | 7R01NS136711-04 |
| Project ID | NIH-11628900 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are individuals with or at risk of spinal cord injury and who can participate in rehabilitation paradigms.
✕Less likely to help
Patients not able to participate in rehabilitation protocols or with injuries outside the corticospinal system may not benefit.
What this research studies
After a spinal cord injury, the brain’s control of the forelimb is altered, and rehabilitation may help rewire the circuits that control movement. The study will examine how rehabilitation influences remodeling of corticospinal neurons and whether these injured neurons can be incorporated into healthy motor networks. Researchers will use models that reveal how training shapes cortical maps and motor outputs. The goal is to identify rehabilitation strategies that best support functional recovery of dexterous forelimb use.
Why it matters
Potential benefit: If successful, the work could lead to better rehabilitation approaches that improve hand and arm function after spinal cord injury.
How similar studies have gone: Previous research suggests that rehabilitation can remodel brain motor maps and aid recovery, but the exact neuronal remodeling process remains under study.
Where this research is happening
-
Weill Medical Coll of Cornell Univ
New York, United States Active
Researchers
- Principal investigator: Hollis, Edmund R — Weill Medical Coll of Cornell Univ
- Study coordinator: Hollis, Edmund R
Related research
Other NIH-funded projects on the same topics.
-
How baclofen and spinal cord stimulation interact in people with spinal cord injury
This study looks at how a common antispasmodic medicine (baclofen) works together with spinal cord stimulation in people who have spinal cord injuries and live with spasticity.
-
Targeting spinal cord inflammation with a new HuR inhibitor to help SCI patients
A new treatment approach uses a small molecule to block a brain-spinal inflammation regulator (HuR) that drives harmful inflammation after spinal cord injury, aiming to lessen damage and pain for people with SCI.
-
From Neural Control of Movement to Treatments for Spinal Cord Injury
A patient-focused project aims to translate how brain signals control movement after spinal cord injury into new treatments that improve muscle function and reduce spasticity.
-
Polaris: a compact system to help motor recovery after spinal cord injury and stroke
A new, easy-to-use device called Polaris may help people with spinal cord injury, stroke, or other chronic conditions regain movement by guiding a specialized reflex-based therapy.
-
Predicting and Preventing Chronic Aspiration After Traumatic Cervical Spinal Cord Injury
This project looks at swallowing problems and chronic aspiration in adults with traumatic neck spine injuries to find patterns that could prevent serious lung complications.
-
Spinal cord neurons that help people stand after spinal cord injury
This project will test whether activating specific spinal cord neurons can help adults with spinal cord injuries regain steady standing and posture.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.