Protecting recovery after spinal cord injury from infection
Official title: Protecting Endogenous Recovery from the "Infectious Insult" in Spinal Cord Injury
Funded at Ohio State University · NIH-11391394 · Data updated 2026-11-12
In people who have a spinal cord injury, getting a pneumonia-like infection may hinder recovery, and this grant studies how to prevent that harm.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project start | September 20, 2024 |
| Project end | August 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $550,011 |
| NIH project number | 5R01NS135237-03 |
| Project ID | NIH-11391394 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are individuals with spinal cord injury who are at risk for or have developed infections, particularly pneumonia, and who could benefit from therapies that protect nervous system recovery.
✕Less likely to help
Patients without spinal cord injury or without infection-related risk to recovery are unlikely to benefit from this research.
What this research studies
This research uses a mouse model of spinal cord injury to see if pneumonia worsens recovery and to identify the factors in the blood and infected areas that drive that damage. It combines brain/spinal cord analysis with models of infection and blood-borne factors to understand how pneumonia could directly affect the injured spinal cord. The goal is to find targets for neuroprotective strategies that could be translated to patients who have SCI and develop infections.
Why it matters
Potential benefit: If successful, findings could lead to new ways to protect spinal cord recovery after infection, potentially improving neurological outcomes for SCI patients.
How similar studies have gone: Animal studies have shown that infections can influence spinal cord recovery, but this project aims to clarify mechanisms and translate findings toward human therapies.
Where this research is happening
-
Ohio State University
Columbus, United States Active
Researchers
- Principal investigator: Filous, Angela R — Ohio State University
- Study coordinator: Filous, Angela R
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.