Vagus nerve stimulation to help people walk again after spinal cord injury
Official title: Enhancing recovery of lower limb function after spinal cord injury
Funded at University of Texas Dallas · NIH-11416268 · Data updated 2026-11-12
A new therapy combines targeted vagus nerve stimulation with walking-focused rehab to help people regain gait after spinal cord injury.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Dallas NIH-funded |
| Lab location | 1 site (Richardson, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $1,194,122 |
| NIH project number | 4UH3NS131971-03 |
| Project ID | NIH-11416268 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with incomplete cervical spinal cord injury who are able to participate in gait rehabilitation and VNS therapy.
✕Less likely to help
Individuals with complete spinal cord injury or those unable to participate in gait rehabilitation may not benefit.
What this research studies
This project aims to translate a nerve-stimulation approach that has shown promise in animals and stroke recovery into a treatment to improve walking after spinal cord injury. It will develop a closed-loop VNS system that triggers stimulation during specific lower-limb rehabilitation exercises. By aligning neuromodulation with physical therapy, the study seeks to enhance brain–spinal cord communication and promote gait recovery in individuals with incomplete cervical SCI. The work will progress from system development to early feasibility in the clinical setting at the University of Texas at Dallas. If successful, this could lay the groundwork for a new, patient-centered rehabilitation option.
Why it matters
Potential benefit: If successful, patients could experience meaningful improvements in walking and mobility after SCI.
How similar studies have gone: Previous work in animals and preliminary human data in upper-limb recovery after stroke suggest that VNS paired with rehab can improve motor outcomes, supporting translation to gait in SCI.
Where this research is happening
-
University of Texas Dallas
Richardson, United States Active
Researchers
- Principal investigator: Rennaker, Robert L — University of Texas Dallas
- Study coordinator: Rennaker, Robert L
Related research
Other NIH-funded projects on the same topics.
-
Corticospinal neurons and recovery of precise forelimb movement after spinal cord injury
This project studies how spine injuries change brain circuits and whether targeted rehabilitation helps restore precise forelimb movement.
-
How baclofen and spinal cord stimulation interact in people with spinal cord injury
This study looks at how a common antispasmodic medicine (baclofen) works together with spinal cord stimulation in people who have spinal cord injuries and live with spasticity.
-
Targeting spinal cord inflammation with a new HuR inhibitor to help SCI patients
A new treatment approach uses a small molecule to block a brain-spinal inflammation regulator (HuR) that drives harmful inflammation after spinal cord injury, aiming to lessen damage and pain for people with SCI.
-
From Neural Control of Movement to Treatments for Spinal Cord Injury
A patient-focused project aims to translate how brain signals control movement after spinal cord injury into new treatments that improve muscle function and reduce spasticity.
-
Polaris: a compact system to help motor recovery after spinal cord injury and stroke
A new, easy-to-use device called Polaris may help people with spinal cord injury, stroke, or other chronic conditions regain movement by guiding a specialized reflex-based therapy.
-
Predicting and Preventing Chronic Aspiration After Traumatic Cervical Spinal Cord Injury
This project looks at swallowing problems and chronic aspiration in adults with traumatic neck spine injuries to find patterns that could prevent serious lung complications.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.