NIH-funded research NIH-funded research

Vagus nerve stimulation to help people walk again after spinal cord injury

Official title: Enhancing recovery of lower limb function after spinal cord injury

Funded at University of Texas Dallas · NIH-11416268 · Data updated 2026-11-12

A new therapy combines targeted vagus nerve stimulation with walking-focused rehab to help people regain gait after spinal cord injury.

More Spinal Cord Injury research and trials

Quick facts

Grant typeNIH-funded research
Study typeNIH-funded research
Funding institutionUniversity of Texas Dallas
NIH-funded
Lab location1 site (Richardson, United States)
Project startSeptember 1, 2024
Project endAugust 31, 2029
Funding year2026
Award (this year)$1,194,122
NIH project number4UH3NS131971-03
Project IDNIH-11416268 on NIH RePORTER

Who could benefit from this research

Could help

Adults with incomplete cervical spinal cord injury who are able to participate in gait rehabilitation and VNS therapy.

Less likely to help

Individuals with complete spinal cord injury or those unable to participate in gait rehabilitation may not benefit.

What this research studies

This project aims to translate a nerve-stimulation approach that has shown promise in animals and stroke recovery into a treatment to improve walking after spinal cord injury. It will develop a closed-loop VNS system that triggers stimulation during specific lower-limb rehabilitation exercises. By aligning neuromodulation with physical therapy, the study seeks to enhance brain–spinal cord communication and promote gait recovery in individuals with incomplete cervical SCI. The work will progress from system development to early feasibility in the clinical setting at the University of Texas at Dallas. If successful, this could lay the groundwork for a new, patient-centered rehabilitation option.

Why it matters

Potential benefit: If successful, patients could experience meaningful improvements in walking and mobility after SCI.

How similar studies have gone: Previous work in animals and preliminary human data in upper-limb recovery after stroke suggest that VNS paired with rehab can improve motor outcomes, supporting translation to gait in SCI.

Where this research is happening

  • University of Texas Dallas
    Richardson, United States
    Active

Researchers

  • Principal investigator: Rennaker, Robert L — University of Texas Dallas
  • Study coordinator: Rennaker, Robert L

Related research

Other NIH-funded projects on the same topics.

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.