CBD for bladder control after spinal cord injury

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This phase 2 pilot feasibility trial gives adult participants with supra‑sacral spinal cord injury purified cannabidiol (Epidiolex) 100 mg twice daily for 90 days to target neurogenic lower urinary tract dysfunction after resolution of spinal shock. Eligible participants must have at least two urinary incontinence episodes per day and meet inclusion/exclusion criteria; key exclusions include recent intravesical Botox, high-dose anticholinergic use, active non-study cannabis use, and certain mood/thought disorders. Study measures include changes in incontinence frequency and other urinary symptoms, feasibility outcomes such as recruitment and adherence, and safety/tolerability monitoring. All dosing and follow-up occur at the University of Wisconsin–Madison with urine drug screening and standardized questionnaires.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* \>18 years of age
* History of supra-sacral spinal cord injury of any mechanism
* Urinary incontinence with ≥2 episodes of urinary incontinence per day (outside of spinal shock)
* Willingness to participate in drug intervention trial
* English-speaking (able to provide consent and complete questionnaires)

Exclusion Criteria:

* History of intravesical Botox
* Actively taking \>15 mg of Oxybutynin single dose or equivalent dose of alternative anticholinergic medication for bladder symptoms
* Use of Cannabis (any form) outside of study as determined by urine drug screen after washout period of 1 month if prior Cannabis use reported
* Thought or mood disorder aside from depression

Where it's running

• University of Wisconsin - Madison
  Madison, Wisconsin, United States Recruiting

Study contacts

• Principal investigator: Javi Santiago — University of Wisconsin, Madison
• Study coordinator: Maria Flory
• Email: flory@ortho.wisc.edu
• Phone: 608-262-8652

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.