Improving bladder function in spinal cord injury patients using neuromodulation

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This trial investigates the safety and effectiveness of spinal cord neuromodulation techniques, specifically transcutaneous electrical stimulation and magnetic stimulation, to enhance urinary bladder function in individuals with spinal cord injury. Participants will undergo these neuromodulation interventions to assess improvements in bladder control and function. The study aims to provide a non-invasive treatment option for neurogenic bladder issues associated with spinal cord injuries.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Male 18-45 years;
2. At least 1 year post-injury;
3. Non-progressive SCI at C2-T8 (non-conus injury);
4. Motor Complete ASIA (A or B);
5. Neurogenic bladder requiring clean intermittent straight catheterization;
6. Able to attend twice weekly testing sessions for 6 months.
7. Have intact lower extremity anatomy and able to use lower extremity for assistive standing and stepping.

Exclusion Criteria:

1. History of autonomic dysreflexia;
2. Ventilator dependency;
3. Musculoskeletal dysfunction, unhealed fracture, pressure ulcer, active infection;
4. Clinically significant depression or ongoing drug abuse;
5. Received botox injection, or bladder surgery (suprapubic access, Brindley procedure, etc.); 6. Prostatic hypertrophy or bladder outlet disorder;

7\. Cardiopulmonary disease that precludes lower extremity training or rehabilitation.

Where it's running

• University of California, Los Angeles
  Los Angeles, California, United States Recruiting

Study contacts

• Study coordinator: Daniel Lu, MD PhD
• Email: dclu@mednet.ucla.edu
• Phone: 310-825-4321

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Implanted Brain-Computer Interface to Help People with Severe Arm Impairment

  We’re testing the N1 System, a fully implanted brain interface in the motor cortex with a robot, to see if it can help adults with spinal cord injury, ALS, or chronic stroke use a computer or keyboard more easily.

  Recruiting Neuralink Corp · Miami, Florida · NCT07929792

• tSCS with rehabilitation for improving movement after spinal cord injury

  This study tests whether adding rehabilitation training to transcutaneous spinal cord stimulation helps paraplegic patients regain voluntary movement after spinal cord injury.

  Recruiting Beijing Tsinghua Chang Gung Hospital · Beijing · NCT07907952

• Informational Needs of Caregivers of Patients in Neuro Rehab: Validating the QBI-R/V

  This study tests a caregiver questionnaire (QBI-R and QBI-V) to see how well it measures caregivers’ informational needs during neuromotor rehabilitation.

  Recruiting at 13 sites Istituti Clinici Scientifici Maugeri SpA · Sciacca, Agrigento and 12 other locations · NCT07903298

• Biomechanical and Perceived Effort in Manual Wheelchair Propulsion

  This study tests whether combining objective shoulder loading data with how hard people feel they’re working can reveal how difficult manual wheelchair propulsion is for users with spinal cord injury.

  Recruiting Centre Médico-Chirurgical de Réadaptation des Massues Croix Rouge Française · Lyon · NCT07897214

• Shockwave therapy added to toxin injections to help spasticity after spinal cord injury

  Aims to see if focused shockwave therapy plus Botox injections reduce spasticity better than Botox alone in adults with spinal cord injury.

  Recruiting Phase 2 Kessler Foundation · West Orange, New Jersey · NCT07894991

• Vibratory Genital Nerve Stimulation to Help Female Sexual Function After Spinal Cord Injury

  This study tests whether a home-use vibration device can improve sexual function in cisgender women with spinal cord injury by increasing genital blood flow during arousal.

  Recruiting Hennepin Healthcare Research Institute · Minneapolis, Minnesota · NCT07870642

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.