Exploring the link between menstrual cycles and urinary incontinence in women with spinal cord injuries

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational pilot study investigates how fluctuations in sex hormones during the menstrual cycle may affect bladder function in women with chronic spinal cord injury. Participants will document their menstrual cycles and instances of urinary incontinence over three cycles, using diaries, saliva samples, and urine tests to gather data. The goal is to identify potential hormonal influences on urinary incontinence, which has been less studied in premenopausal women compared to postmenopausal women. Understanding these factors could lead to improved treatment options for affected individuals.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* women
* age ≥ 18 years
* chronic neurogenic bladder dysfunction due to acquired spinal cord injury
* regular menstrual cycle (26-30 days/cycle)
* written consent given
* UI group only: UI at least once per month

Exclusion Criteria:

* Detrusor overactivity in storage phase above 15cmH20
* Oligomenorrhea or amenorrhea (infrequent or absent menstrual periods)
* Hormonal intake/contraception
* Intake of androgens
* Intake of drugs which interfere with female sex hormones significantly
* Individuals who underwent sex reassignment surgery
* Pregnant or breastfeeding women
* Women who are trying to conceive
* Gynaecological carcinoma
* Endometriosis
* Ovariectomy
* Current pelvic floor physiotherapy
* Reconstructive surgery of bladder
* Local irritation of the bladder, such as bladder tumour, bladder stones, acute urinary tract infection at study start
* Inability to follow study procedures (cognitive or language barriers)

Where it's running

• Swiss Paraplegic Center
  Nottwil, Switzerland Recruiting

Study contacts

• Study coordinator: Jörg Krebs, Dr. med. vet. / PhD
• Email: joerg.krebs@paraplegie.ch
• Phone: +41 41 939 59 46

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.