Investigating the role of LINE1 and IFI16 in Sjögren's syndrome
Official title: The Retroelement LINE1 and the DNA Sensor IF16 in Sjogren's Syndrome
Funded at Johns Hopkins University · NIH-11036271 · Data updated 2026-11-12
This study is looking at how a specific part of our DNA interacts with the immune system in people with Sjögren's syndrome, which could help us understand the disease better and find new ways to treat it.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | March 1, 2021 |
| Project end | February 28, 2026 |
| Funding year | 2025 |
| Award (this year) | $158,755 |
| NIH project number | 5K08AR077100-05 |
| Project ID | NIH-11036271 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Sjögren's syndrome, particularly those exhibiting specific immune responses related to LINE1 and IFI16.
✕Less likely to help
Patients with Sjögren's syndrome who do not have detectable autoantibodies or those with other unrelated autoimmune conditions may not benefit from this research.
What this research studies
This research focuses on understanding how the retroelement LINE1 interacts with the DNA sensor IFI16 in patients with Sjögren's syndrome, an autoimmune disease. The study aims to explore how these interactions may drive immune responses against the body's own nucleic acids, contributing to the symptoms of the disease. By examining the role of autophagy in regulating these immune responses, the research seeks to uncover new insights into the mechanisms behind Sjögren's syndrome. Patients may benefit from a better understanding of their condition and potential new therapeutic targets.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients with Sjögren's syndrome by identifying new targets for therapy.
How similar studies have gone: Previous research has shown promising results in understanding the role of immune responses in autoimmune diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Antiochos, Brendan — Johns Hopkins University
- Study coordinator: Antiochos, Brendan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.