Finding ways to reduce inflammation and help salivary glands heal in Sjogren's syndrome
Official title: Controlling Autoimmune Inflammation and Promoting Salivary Gland Regeneration in Sjogren's Syndrome
Funded at Ada Forsyth Institute, INC. · NIH-10657745 · Data updated 2026-11-12
This study is looking at how special substances can help heal the salivary glands in people with Sjogren's syndrome, aiming to improve dry mouth and overall health.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ada Forsyth Institute, INC. NIH-funded |
| Lab location | 1 site (Cambridge, United States) |
| Project start | July 1, 2022 |
| Project end | June 30, 2025 |
| Funding year | 2023 |
| Award (this year) | $298,500 |
| NIH project number | 5R21DE031058-02 |
| Project ID | NIH-10657745 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Sjogren's syndrome who experience symptoms related to salivary gland dysfunction.
✕Less likely to help
Patients without Sjogren's syndrome or those who do not have salivary gland dysfunction may not benefit from this research.
What this research studies
This research focuses on Sjogren's syndrome, an autoimmune condition that leads to inflammation and damage of salivary glands, causing dry mouth and other health issues. The project aims to explore the use of specialized pro-resolving mediators (SPMs) to enhance the healing and immune-regulatory functions of salivary gland stem cells. By studying these mediators both in laboratory settings and in living organisms, the researchers hope to develop new strategies that can effectively regenerate damaged salivary glands and improve patient outcomes.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that restore salivary gland function and alleviate symptoms for patients with Sjogren's syndrome.
How similar studies have gone: While stem cell therapies for Sjogren's syndrome are promising, the specific use of SPMs in this context is relatively novel and has not been extensively tested in prior studies.
Where this research is happening
-
Ada Forsyth Institute, INC.
Cambridge, United States Active
Researchers
- Principal investigator: Yu, Qing — Ada Forsyth Institute, INC.
- Study coordinator: Yu, Qing
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.