Identifying genetic factors that increase the risk of Sjögren's syndrome
Official title: Discovery and Characterization of Genetic Risk Loci in Sjogren's Syndrome
Funded at Oklahoma Medical Research Foundation · NIH-10907847 · Data updated 2026-11-12
This study is looking at the genes that might play a role in Sjögren's syndrome, a condition that causes dryness and fatigue, to help find better treatments for people living with it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oklahoma Medical Research Foundation NIH-funded |
| Lab location | 1 site (Oklahoma City, United States) |
| Project start | September 7, 2020 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $721,627 |
| NIH project number | 5R01AR073855-05 |
| Project ID | NIH-10907847 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Sjögren's syndrome, particularly those experiencing severe symptoms.
✕Less likely to help
Patients with Sjögren's syndrome who do not have a genetic predisposition or those with other unrelated autoimmune conditions may not benefit from this research.
What this research studies
This research investigates the genetic factors that contribute to Sjögren's syndrome, an autoimmune disorder that primarily affects the exocrine glands, leading to symptoms like dryness and fatigue. The study involves collaboration among multiple research groups to analyze genetic data from patients, aiming to identify specific genetic risk loci associated with the condition. By understanding these genetic markers, the research seeks to uncover how they influence immune cell behavior and contribute to the disease's progression. This could ultimately lead to the development of targeted therapies for patients suffering from Sjögren's syndrome.
Why it matters
Potential benefit: If successful, this research could lead to new treatment options and improved management strategies for patients with Sjögren's syndrome.
How similar studies have gone: Previous research has successfully identified genetic risk factors in other autoimmune diseases, suggesting that this approach may yield valuable insights for Sjögren's syndrome as well.
Where this research is happening
-
Oklahoma Medical Research Foundation
Oklahoma City, United States Active
Researchers
- Principal investigator: Lessard, Christopher J — Oklahoma Medical Research Foundation
- Study coordinator: Lessard, Christopher J
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.