Glycolytic metabolites, Calcium entry, and Sjögren’s syndrome
Official title: Glycolytic metabolites, Calcium entry and Sjogren’s syndrome
Funded at University of Texas Hlth Science Center · NIH-11359626 · Data updated 2026-11-12
A patient-focused look at how tiny changes in metabolism and calcium signaling might contribute to Sjögren’s syndrome and its effects on saliva.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Science Center NIH-funded |
| Lab location | 1 site (San Antonio, United States) |
| Project start | September 19, 2022 |
| Project end | June 30, 2027 |
| Funding year | 2026 |
| Award (this year) | $563,834 |
| NIH project number | 5R01DE031716-05 |
| Project ID | NIH-11359626 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideally, adults with Sjögren’s syndrome or related salivary gland dysfunction may benefit from future therapies stemming from this work.
✕Less likely to help
Patients without Sjögren’s syndrome or salivary gland issues may not directly benefit from this research.
What this research studies
This project explores how immune cells and saliva gland function interact in Sjögren’s syndrome, a condition where the mouth and eyes can feel dry. It examines how lactate, a metabolite from our cells, might influence calcium channels and ER stress in salivary glands, potentially driving disease processes. The study combines biological experiments to understand these links with the goal of identifying targets that could protect saliva production in patients. Participants would be indirectly affected by future therapies that arise from understanding these mechanisms.
Why it matters
Potential benefit: If successful, the research could lead to new ways to prevent or treat salivary gland dysfunction in Sjögren’s syndrome, improving comfort and quality of life.
How similar studies have gone: Previous work suggests metabolism and calcium signaling influence immune and gland function, with potential for new therapeutic targets in Sjögren’s syndrome.
Where this research is happening
-
University of Texas Hlth Science Center
San Antonio, United States Active
Researchers
- Principal investigator: Singh, Brij B — University of Texas Hlth Science Center
- Study coordinator: Singh, Brij B
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.