Understanding T cell interactions in Sjogren’s syndrome and exploring genetic treatments
Official title: Mapping the T cell receptor/antigen complex and identifying the genetic-based treatment in Sjogren’s syndrome
Funded at University of Florida · NIH-10599844 · Data updated 2026-11-12
This study is looking at how certain T cell receptors might play a role in Sjogren’s syndrome, which causes dry mouth and dry eyes, to help find new treatments for people dealing with this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project start | April 1, 2019 |
| Project end | March 31, 2026 |
| Funding year | 2023 |
| Award (this year) | $432,249 |
| NIH project number | 5R01DE028544-05 |
| Project ID | NIH-10599844 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Sjogren’s syndrome, particularly those experiencing severe symptoms.
✕Less likely to help
Patients with other autoimmune diseases that do not involve T cell receptor interactions specific to Sjogren’s syndrome may not benefit from this research.
What this research studies
This research investigates the role of T cell receptors in Sjogren’s syndrome, an autoimmune condition that primarily affects the salivary and lacrimal glands, leading to symptoms like dry mouth and dry eyes. By studying the genetic makeup of T cells in patients, the research aims to identify specific T cell receptors that contribute to the disease. The approach includes using animal models and human samples to map these receptors and understand how they interact with glandular cells. This could lead to targeted genetic-based treatments for patients suffering from this condition.
Why it matters
Potential benefit: If successful, this research could lead to more effective, personalized treatments for patients with Sjogren’s syndrome.
How similar studies have gone: Previous research has shown promise in understanding T cell interactions in autoimmune diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Florida
Gainesville, United States Active
Researchers
- Principal investigator: Nguyen, Cuong Q — University of Florida
- Study coordinator: Nguyen, Cuong Q
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.