Investigating mitochondrial RNA in pediatric Sjogren's syndrome
Official title: Cytoplasmic mitochondrial dsRNA in pediatric Sjogren's syndrome
Funded at University of Florida · NIH-10287866 · Data updated 2026-11-12
This study is looking at a rare type of Sjogren's syndrome in kids and teens to help tell it apart from other similar conditions, and it will explore how their immune systems work to better understand this autoimmune disease.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project start | September 22, 2021 |
| Project end | August 31, 2025 |
| Funding year | 2021 |
| Award (this year) | $369,050 |
| NIH project number | 1R21AR079693-01 |
| Project ID | NIH-10287866 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children and adolescents diagnosed with Sjogren's syndrome or those exhibiting symptoms consistent with this condition.
✕Less likely to help
Patients who are adults or do not have symptoms related to Sjogren's syndrome are unlikely to benefit from this research.
What this research studies
This research focuses on understanding a rare form of Sjogren's syndrome that affects children and adolescents. It aims to differentiate pediatric Sjogren's syndrome from other conditions that cause similar symptoms, such as recurrent parotitis. The study will analyze immune responses and the role of mitochondrial RNA in these patients, using advanced techniques like RNA sequencing and gene expression analysis. By examining the immune dysregulation in pediatric patients, the research seeks to uncover the underlying mechanisms of this autoimmune condition.
Why it matters
Potential benefit: If successful, this research could lead to better diagnosis and treatment options for children suffering from Sjogren's syndrome.
How similar studies have gone: While research on Sjogren's syndrome is ongoing, this specific focus on pediatric cases and mitochondrial RNA is relatively novel and has not been extensively tested.
Where this research is happening
-
University of Florida
Gainesville, United States Active
Researchers
- Principal investigator: Cha, Seunghee — University of Florida
- Study coordinator: Cha, Seunghee
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.