Investigating mitochondrial RNA in pediatric Sjogren's syndrome
Cytoplasmic mitochondrial dsRNA in pediatric Sjogren's syndrome
['FUNDING_R21'] · UNIVERSITY OF FLORIDA · NIH-10287866
This study is looking at a rare type of Sjogren's syndrome in kids and teens to help tell it apart from other similar conditions, and it will explore how their immune systems work to better understand this autoimmune disease.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF FLORIDA (nih funded) |
| Locations | 1 site (GAINESVILLE, UNITED STATES) |
| Trial ID | NIH-10287866 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding a rare form of Sjogren's syndrome that affects children and adolescents. It aims to differentiate pediatric Sjogren's syndrome from other conditions that cause similar symptoms, such as recurrent parotitis. The study will analyze immune responses and the role of mitochondrial RNA in these patients, using advanced techniques like RNA sequencing and gene expression analysis. By examining the immune dysregulation in pediatric patients, the research seeks to uncover the underlying mechanisms of this autoimmune condition.
Who could benefit from this research
Good fit: Ideal candidates for this research are children and adolescents diagnosed with Sjogren's syndrome or those exhibiting symptoms consistent with this condition.
Not a fit: Patients who are adults or do not have symptoms related to Sjogren's syndrome are unlikely to benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better diagnosis and treatment options for children suffering from Sjogren's syndrome.
How similar studies have performed: While research on Sjogren's syndrome is ongoing, this specific focus on pediatric cases and mitochondrial RNA is relatively novel and has not been extensively tested.
Where this research is happening
GAINESVILLE, UNITED STATES
- UNIVERSITY OF FLORIDA — GAINESVILLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CHA, SEUNGHEE — UNIVERSITY OF FLORIDA
- Study coordinator: CHA, SEUNGHEE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.