Analyzing exosomes to understand Sjogren's and dry eye syndromes
Official title: Systemic Proteomic Analysis of Plasma Exosomes to Explore the Immunomodulation Reflected to Sjogren's Syndrome and Dry Eye Syndrome
Run by Taipei Veterans General Hospital, Taiwan · NCT06771427 · Data updated 2026-11-12
This study is trying to see if looking at tiny particles in the body can help us understand Sjogren's Syndrome and Dry Eye Syndrome better, while also testing acupuncture and herbal tea as possible treatments for these conditions.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 20 Years to 75 Years |
| Sex | All |
| Enrollment | 220 (estimated) |
| Sponsor | Taipei Veterans General Hospital, Taiwan Government |
| Locations | 1 site (Taipei, Taiwan) |
| Status | Recruiting |
| Started | January 16, 2025 |
| Main results expected | April 30, 2025 |
| Study ends | December 31, 2026 |
| Registry record updated | January 17, 2025 |
| Trial ID | NCT06771427 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are individuals aged 20 to 75 years diagnosed with Dry Eye Syndrome or Sjogren's Syndrome.
✕Probably not a fit
Patients with active eye inflammation, infectious eye diseases, or those with a history of certain chronic conditions may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study focuses on the analysis of differential proteins in exosomes to uncover the pathological mechanisms behind Sjogren's Syndrome (SJS) and Dry Eye Syndrome (DES). By building on previous research, the study aims to identify potential diagnostic and therapeutic methods that could enhance the understanding and treatment of these conditions. Participants will include individuals with SJS, DES, and healthy controls, with specific inclusion and exclusion criteria to ensure appropriate patient selection. The study will also explore the effects of acupuncture and Chinese herbal tea as potential interventions.
Why it matters
Potential benefit: If successful, this study could lead to improved diagnostic and therapeutic strategies for patients suffering from Sjogren's and dry eye syndromes.
How similar studies have gone: While there have been studies utilizing exosome proteomics in various diseases, this specific focus on Sjogren's and dry eye syndromes is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Dry eye syndrome Inclusion Criteria: aged between 20 and 75 years Schirmer's test less than 10 mm/5 min Exclusion Criteria: Pregnancy With eye inflammation or infectious eye disease Accepted operation of eye Sjögren's syndrome Inclusion Criteria: primary or secondary SS aged between 20 and 75 years fulfilled the 2002 American-European Consensus Criteria for SS (AECG) had no abnormal findings of immune, liver, kidney, or blood function evaluations. Exclusion Criteria: a history of alcohol abuse, diabetes mellitus, or major life-threatening condition pregnancy or breastfeeding steroid pulse therapy within three months prior to the commencement of our study. non AIDDES Healthy Controls Inclusion Criteria: aged between 20 and 75 years without any Chronic disease Exclusion Criteria: any Sjögren's syndrome or Dry eye syndrome.
Where it's running
-
Ching-Mao
Taipei, Taiwan, Taiwan Recruiting
Study contacts
- Principal investigator: Ching-Mao Chang, M.D., Ph.D. — Taipei Veterans General Hospital, Taiwan
- Study coordinator: Ching-Mao Chang, M.D., Ph.D.
- Email: magicbjp@gmail.com
- Phone: 8862285757453
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.