How aging and oxidative stress affect salivary gland disease in Sjögren’s Syndrome
Official title: Aging and Oxidative Stress Influence Salivary Gland Disease in Sjogren's Syndrome
Funded at Oklahoma Medical Research Foundation · NIH-11013397 · Data updated 2026-11-12
This study is looking at how getting older and stress in the body might affect the salivary glands in people with Sjögren’s Syndrome, with the hope of finding better ways to treat and manage the condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oklahoma Medical Research Foundation NIH-funded |
| Lab location | 1 site (Oklahoma City, United States) |
| Project start | April 1, 2023 |
| Project end | January 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $508,110 |
| NIH project number | 5R01DE032911-03 |
| Project ID | NIH-11013397 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults, particularly those diagnosed with Sjögren’s Syndrome.
✕Less likely to help
Patients who are younger than 65 or do not have Sjögren’s Syndrome may not benefit from this research.
What this research studies
This research investigates the relationship between aging, oxidative stress, and salivary gland disease in patients with Sjögren’s Syndrome, a chronic autoimmune disorder. The study aims to understand how oxidative stress, which increases with age, may make salivary glands more vulnerable to immune damage. Researchers will utilize a novel mouse model to explore these mechanisms and their implications for the disease. By examining these factors, the research seeks to uncover potential pathways for improving treatment and management of Sjögren’s Syndrome.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and management of Sjögren’s Syndrome, potentially improving quality of life for affected patients.
How similar studies have gone: While the specific approach of this research is novel, previous studies have shown that understanding the role of oxidative stress in autoimmune diseases can lead to significant insights.
Where this research is happening
-
Oklahoma Medical Research Foundation
Oklahoma City, United States Active
Researchers
- Principal investigator: Deshmukh, Umesh S — Oklahoma Medical Research Foundation
- Study coordinator: Deshmukh, Umesh S
Related research
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.