Investigating how glycolytic metabolites and calcium entry affect Sjögren's syndrome
Official title: Glycolytic metabolites, Calcium entry and Sjogren’s syndrome
Funded at University of Texas Hlth Science Center · NIH-10855763 · Data updated 2026-11-12
This study is looking at how certain substances in the body, like lactate, affect immune cells in people with Primary Sjögren's syndrome, which can cause dry mouth and other issues, to find new ways to help improve salivary gland function.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Science Center NIH-funded |
| Lab location | 1 site (San Antonio, United States) |
| Project start | September 19, 2022 |
| Project end | June 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $552,558 |
| NIH project number | 5R01DE031716-03 |
| Project ID | NIH-10855763 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Primary Sjögren's syndrome who experience salivary gland dysfunction.
✕Less likely to help
Patients without a diagnosis of Sjögren's syndrome or those with other unrelated autoimmune conditions may not benefit from this research.
What this research studies
This research focuses on understanding the role of glycolytic metabolites, particularly lactate, and calcium entry in the development of Primary Sjögren's syndrome (pSS), an autoimmune disease that affects salivary glands. The study aims to explore how immune cells infiltrate salivary tissues and how lactate levels influence immune responses and calcium channel activity in these cells. By examining these mechanisms, the research seeks to uncover potential therapeutic targets for improving salivary gland function in affected patients.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve salivary gland function and overall oral health for patients with Sjögren's syndrome.
How similar studies have gone: Previous research has shown that targeting metabolic pathways can influence immune responses, suggesting that this approach may yield promising results.
Where this research is happening
-
University of Texas Hlth Science Center
San Antonio, United States Active
Researchers
- Principal investigator: Singh, Brij B — University of Texas Hlth Science Center
- Study coordinator: Singh, Brij B
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.