Understanding the immune cells involved in Sjögren's syndrome
Specificity and Molecular Definition of Pathogenic Lymphocytes in Sjogren's Syndrome
This study is looking at certain immune cells in people with Sjögren's syndrome to understand what triggers the immune response, which could help find new ways to treat the condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oklahoma Medical Research Foundation NIH-funded |
| Lab location | 1 site (Oklahoma City, United States) |
| Project ID | NIH-10469419 on NIH RePORTER |
What this research studies
This research investigates the specific immune cells, particularly B lymphocytes and T cells, that contribute to Sjögren's syndrome, an autoimmune disease affecting the salivary and lacrimal glands. By analyzing the genetic and molecular characteristics of these cells, the study aims to identify the antigens that trigger the immune response in affected patients. The researchers will utilize advanced techniques to isolate and characterize these immune cells and their interactions, which could lead to new insights into the disease's pathology and potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Sjögren's syndrome, particularly those experiencing severe symptoms like dry mouth and eyes.
Not a fit: Patients with Sjögren's syndrome who do not have significant immune cell involvement or those with other unrelated conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of effective biologic therapies for Sjögren's syndrome, improving the quality of life for patients.
How similar studies have performed: Previous research has shown promising results in understanding immune cell roles in autoimmune diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
Oklahoma City, United States
- Oklahoma Medical Research Foundation — Oklahoma City, United States (Active)
Researchers
- Principal investigator: Farris, a Darise — Oklahoma Medical Research Foundation
- Study coordinator: Farris, a Darise
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.