Investigating the role of autoantibodies in Sjögren's syndrome
Official title: Sjogren's Syndrome Pathogenic Autoantibodies
Funded at Oklahoma Medical Research Foundation · NIH-10854472 · Data updated 2026-11-12
This study is looking at how certain immune cells in the salivary glands of people with Sjögren's syndrome create antibodies that might make dry mouth and dry eyes worse, with the hope of finding new ways to help manage the condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oklahoma Medical Research Foundation NIH-funded |
| Lab location | 1 site (Oklahoma City, United States) |
| Project start | August 1, 2023 |
| Project end | July 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $291,045 |
| NIH project number | 7R01DE028001-05 |
| Project ID | NIH-10854472 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Sjögren's syndrome who experience symptoms such as dry eyes and dry mouth.
✕Less likely to help
Patients with autoimmune conditions other than Sjögren's syndrome may not receive direct benefits from this research.
What this research studies
This research focuses on Sjögren's syndrome, an autoimmune disease that primarily affects the glands responsible for producing saliva and tears, leading to symptoms like dry mouth and dry eyes. The study aims to understand how certain B cells in the salivary glands produce autoantibodies that contribute to glandular dysfunction. By examining the presence of specific autoantibodies in patients' serum and their correlation with disease symptoms, the research seeks to uncover the mechanisms behind this condition. The findings could help identify new therapeutic targets for managing Sjögren's syndrome.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients suffering from Sjögren's syndrome by targeting the underlying causes of glandular dysfunction.
How similar studies have gone: Previous research has shown success in understanding the role of autoantibodies in autoimmune diseases, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Oklahoma Medical Research Foundation
Oklahoma City, United States Active
Researchers
- Principal investigator: Scofield, Robert Hal — Oklahoma Medical Research Foundation
- Study coordinator: Scofield, Robert Hal
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.