Condition

Peripheral Artery Disease clinical trials and research

• 42Clinical trials
• 57NIH research projects
• 16Countries

Newest Peripheral Artery Disease clinical trials

All recruiting trials (42)

• Antiplatelet-Only versus Antiplatelet plus Low-Dose Rivaroxaban after Heart Events

  In adults 65 or older with prior heart events and certain arterial diseases, this study tests whether continuing clopidogrel alone is no worse than adding low-dose rivaroxaban to aspirin-based therapy.

  Recruiting Phase 4 Seoul National University Bundang Hospital · Seongnam-si, Gyeonggi-do · NCT07796217

• Home-based Pedal Exerise Therapy for Moderate-to-Severe PAD

  This pilot study tests whether a 12-week home-based pedal exerciser program, guided remotely, can help adults with moderate-to-severe PAD improve walking and function.

  Recruiting Laval University · Lévis, Quebec · NCT07655206

• Super-resolution ultrasound imaging for peripheral artery disease

  This project will test whether super-resolution contrast ultrasound can reveal small-vessel problems in adults with or without peripheral artery disease.

  Recruiting Peking University First Hospital · Beijing, Beijing Municipality · NCT07374601

• Obstructive sleep apnea prevalence in people with peripheral artery disease

  This project will test how common obstructive sleep apnea is in adults with peripheral artery disease by using sleep polygraphy during routine care.

  Recruiting Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer · Toulon, Var · NCT07283289

• Using wearable activity trackers and a mobile app to help people with peripheral artery disease walk better

  This project will test whether a personalized home walking program guided by wearable activity trackers and automatic feedback can help people with peripheral artery disease walk as well as supervised exercise sessions.

  Recruiting at 2 sites Chinese University of Hong Kong · Hong Kong, Hong Kong and 1 other locations · NCT07012070

• Evaluating a Paclitaxel Coated Balloon for Treating Atherosclerosis in Leg Arteries

  This study is testing a special balloon treatment to see if it can safely improve blood flow and reduce symptoms in people with blocked leg arteries due to peripheral artery disease.

  Recruiting at 2 sites Balton Sp.zo.o. · Chrzanów, Malopolska and 2 other locations · NCT06734221

• Helping people walk better after leg revascularization for peripheral artery disease

  This project will see if adding a home-based walking program or taking nitrate-rich beetroot juice after leg revascularization helps people with peripheral artery disease walk farther and faster.

  Recruiting at 8 sites Phase 3 Northwestern University · Tucson, Arizona and 7 other locations · NCT06686121

• Exercise and Nitric Oxide Effects in Peripheral Artery Disease

  This study is testing if a 12-week exercise program can boost nitric oxide levels in people with Peripheral Artery Disease and whether drinking beetroot juice can help those who don't see improvements from exercise.

  Recruiting Phase 2 Northwestern University · Chicago, Illinois and 1 other locations · NCT06657976

• Evaluating cardiovascular events in diabetic patients using HEMOTAG

  This study is testing how well the HEMOTAG device can help track heart problems in people with Type 2 Diabetes who also have other heart risk factors.

  Recruiting Aventusoft, LLC. · West Palm Beach, Florida · NCT06567795

• Using light therapy to enhance walking in patients with peripheral artery disease

  This study is testing if daily light therapy can help people with peripheral artery disease walk farther and improve their overall health when combined with home exercises.

  Recruiting Northwestern University · Chicago, Illinois · NCT06399900

• Effects of a medication on blood vessel function and walking ability in people with peripheral artery disease

  This study is testing if a medication called diroximel fumarate can help improve blood vessel function and walking ability in people aged 50-75 with peripheral artery disease.

  Recruiting Early Phase 1 University of Nebraska · Omaha, Nebraska · NCT06319339

• Assessing the Systolic Rise Time's ability to predict limb and cardiovascular events in severe peripheral artery disease

  This study is testing if a specific measurement from the foot can help predict serious problems with limbs and heart health in people with severe peripheral artery disease.

  Recruiting Centre Hospitalier Universitaire, Amiens · Amiens · NCT06318767

• Using computerized alerts to improve cholesterol treatment in patients with Peripheral Artery Disease

  This study is testing a new computer alert system to see if it can help doctors prescribe cholesterol-lowering medications more often for patients with Peripheral Artery Disease who aren't currently on them.

  Recruiting Brigham and Women's Hospital · Boston, Massachusetts · NCT06300450

• Using AI to analyze the superficial femoral artery for better treatment of artery disease

  This study is testing if an AI tool can help doctors better understand the types of plaque in the superficial femoral artery from CT scans to improve treatment for people with peripheral artery disease.

  Recruiting University Hospital, Strasbourg, France · Strasbourg, Bas-Rhin · NCT06260488

• Comparing a combination of rosuvastatin and ezetimibe to rosuvastatin alone for patients with peripheral artery disease

  This study is testing if taking both rosuvastatin and ezetimibe together can help people with peripheral artery disease have fewer heart and leg problems compared to just taking rosuvastatin alone.

  Recruiting Yonsei University · Seoul · NCT06231966

• Heart muscle strain imaging in people with lower limb artery disease

  This study tests whether people with lower extremity arterial disease have subtle heart muscle problems detected by strain imaging that relate to changes in blood metabolites.

  Recruiting Tartu University Hospital · Tartu · NCT06215248

• Improving physical activity in patients with Peripheral Artery Disease using electrical stimulation and behavior change

  This study is testing whether a combination of walking exercises and electrical stimulation can help people with Peripheral Artery Disease be more active and improve their quality of life.

  Recruiting Glasgow Caledonian University · Glasgow, Lanarkshire · NCT06114732

• Evaluating anesthesia types for lower limb surgery

  This study is trying to see if using different types of anesthesia during lower limb surgery can improve recovery for adults who are scheduled for these procedures.

  Recruiting Ottawa Hospital Research Institute · Ottawa, Ontario · NCT06067789

• Calf stretching therapy for improving health in patients with peripheral artery disease

  This study is testing if using inflatable ankle splints to stretch calf muscles can help people with peripheral artery disease walk better and improve their leg health.

  Recruiting Penn State University · University Park, Pennsylvania · NCT06041880

• Home-based walking program for veterans with peripheral artery disease

  This study is testing two ways to deliver a home walking program for veterans with peripheral artery disease to see if it helps them walk farther and feel better.

  Recruiting VA Office of Research and Development · Birmingham, Alabama and 2 other locations · NCT06033924

• Evaluation of clinical results for patients with aorta and peripheral artery revascularization

  This study looks at the long-term health results of around 6,000 patients who have had surgery to improve blood flow in their aorta and legs.

  Recruiting Asan Medical Center · Seoul · NCT06022653

• Oxygen-guided exercise program for patients with peripheral artery disease

  This study tests a new exercise program that uses muscle oxygen levels to help people with peripheral artery disease walk better and feel healthier without the usual risks of traditional exercise.

  Recruiting VA Office of Research and Development · Omaha, Nebraska · NCT06003855

• Testing the Thor system for treating blocked leg arteries

  This study is testing a new treatment called the Thor system to see if it can safely help adults with blocked leg arteries due to peripheral artery disease.

  Recruiting at 27 sites Philips Clinical & Medical Affairs Global · St. Helena, California and 28 other locations · NCT05916950

• Non-painful exercise program for patients with Peripheral Artery Disease

  This study is testing a new exercise program that doesn’t cause pain to see if it can help people with Peripheral Artery Disease walk better and improve their quality of life.

  Recruiting University of Oklahoma · Oklahoma City, Oklahoma · NCT05712395

• Biorepository for cardiovascular and metabolic disease research

  This study is collecting blood, urine, and stool samples from people with heart and metabolic diseases to help researchers better understand these conditions and improve care.

  Recruiting The Cleveland Clinic · Cleveland, Ohio · NCT05628948

• Using beetroot juice to improve walking in patients with peripheral artery disease

  This study is testing if drinking beetroot juice can help people with peripheral artery disease walk better.

  Recruiting at 3 sites Northwestern University · Chicago, Illinois and 3 other locations · NCT05624125

• Drug-coated balloon angioplasty for below the knee arterial lesions

  This study is testing whether a special drug-coated balloon treatment can help people with severe leg circulation problems heal better and avoid complications.

  Recruiting at 10 sites Liyuan Hospital of Tongji Medical College, Huazhong University of Science and Technology · Beijing, Beijing Municipality and 9 other locations · NCT05620095

• Home-based leg heat therapy for improving walking in patients with peripheral artery disease

  This study is testing if a home-based leg heat therapy can help people with peripheral artery disease walk better and improve their quality of life.

  Recruiting Indiana University · Indianapolis, Indiana · NCT05465070

• Registry for patients with Peripheral Artery Disease

  This study is collecting health information from people with peripheral artery disease to see how they do over the next 10 years with different treatments.

  Recruiting Federico II University · Naples · NCT04903912

• Evaluating a new drug-coated balloon for treating below-the-knee artery lesions

  This study is testing a new drug-coated balloon treatment for people with peripheral artery disease to see if it helps improve blood flow in their lower legs.

  Recruiting Acotec Scientific Co., Ltd · Beijing, Beijing Municipality · NCT04885985

• Testing cocoa flavanols for improving walking distance in patients with peripheral artery disease

  This study is testing if cocoa flavanols can help older adults with peripheral artery disease walk farther and improve their overall mobility.

  Recruiting at 3 sites Phase 3 Northwestern University · Chicago, Illinois and 2 other locations · NCT04794530

• Sirolimus drug coated balloon treatment for below the knee arterial disease

  This study is testing if a new sirolimus drug-coated balloon can help people with peripheral artery disease have better results than the standard treatment for below the knee arterial problems.

  Recruiting at 17 sites Concept Medical Inc. · Singapore and 19 other locations · NCT04511247

• Sirolimus drug coated balloon for treating artery disease

  This study is testing if a special balloon coated with sirolimus can help people with peripheral artery disease by reducing the chance of their arteries narrowing again compared to regular balloons.

  Recruiting at 17 sites Concept Medical Inc. · Singapore and 19 other locations · NCT04511234

• Temsirolimus injected around below-knee arteries to improve angioplasty or atherectomy results

  This trial will test whether injecting low-dose temsirolimus around below-knee arteries at the time of angioplasty or atherectomy reduces amputations and the need for repeat procedures in people with symptomatic peripheral artery disease or critical limb ischemia.

  Recruiting at 2 sites Phase 3 Mercator MedSystems, Inc. · Houma, Louisiana and 1 other locations · NCT04433572

• Follow-up on the use of drug-coated balloons for treating peripheral artery disease

  This study is trying to see how well AcoArt drug-coated balloons work and how safe they are for people with peripheral artery disease who have either leg pain or severe circulation problems.

  Recruiting at 7 sites Acotec Scientific Co., Ltd · Halle, Saxony-Anhalt and 6 other locations · NCT04393389

• Registry of long-term antithrombotic therapy for coronary artery disease

  This study looks at how safe and effective long-term blood-thinning treatments are for people with coronary artery disease, including those who have had heart attacks or heart surgeries.

  Recruiting National Medical Research Center for Cardiology, Ministry of Health of Russian Federation · Moscow · NCT04347200

• Community-based exercise program for patients after revascularization for PAD

  This study is testing if a community-based exercise program can help people with peripheral artery disease feel better and improve their health after they have had surgery to restore blood flow.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT04252950

• Effects of diet and exercise on patients with peripheral artery disease

  This study is testing whether a special diet and exercise program together can help people with peripheral artery disease walk better and feel healthier compared to just exercising at home.

  Recruiting University of Oklahoma · Oklahoma City, Oklahoma · NCT03845036

• Comparing drug-coated balloons and plain balloons for stenting in leg arteries

  This study is testing whether using drug-coated balloons works better than regular balloons for treating blocked leg arteries in certain patients.

  Recruiting at 3 sites Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University · Shanghai, Shanghai Municipality and 2 other locations · NCT03791970

• Imaging blood flow in patients with peripheral artery disease

  This study is testing how imaging blood flow in the legs can help doctors understand and improve treatment for people with peripheral artery disease who are having surgery to restore blood flow.

  Recruiting Nationwide Children's Hospital · Columbus, Ohio · NCT03622359

• Red light treatment for improving blood flow in peripheral artery disease

  This study is testing if a short exposure to red light can improve blood flow in the legs of people with peripheral artery disease.

  Recruiting University of Alabama at Birmingham · Milwaukee, Wisconsin · NCT03203239

• Evaluating exercise testing in patients with Peripheral Artery Disease

  This study is trying to see how exercise testing can help understand the challenges faced by people with Peripheral Artery Disease (PAD).

  Recruiting Rennes University Hospital · Rennes · NCT03186391

NIH-funded research (newest 40 of 57)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Low-dose colchicine to reduce vascular risk in people with peripheral artery disease

  This project tests whether taking a low-dose anti-inflammatory drug (colchicine) daily can lower heart and limb-related risks for adults with peripheral artery disease.

  NIH research Duke University · Durham, United States · NIH-11624874

• Gamified home walking program to help seniors with peripheral artery disease improve walking and quality of life

  A program uses game elements on wearable devices to help people 65+ with peripheral artery disease walk more at home and feel better.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11449859

• Fatty clues in leg arteries: how fat burning in mitochondria affects PAD and muscle health

  This project looks at how fat metabolism in leg muscles relates to weakness and tissue damage in people with peripheral artery disease and aims to find new ways to help them.

  NIH research Wake Forest University Health Sciences · Winston-Salem, United States · NIH-11447448

• Enhancing muscle energy to help leg function in PAD

  A study to boost how muscle mitochondria work in people with peripheral artery disease to improve walking and leg function.

  NIH research University of Florida · Gainesville, United States · NIH-11427216

• Low-dose colchicine for people with peripheral artery disease to reduce heart and limb risks

  A large international study will test whether a low daily dose of colchicine can lower heart and limb complications for people with peripheral artery disease.

  NIH research Duke University · Durham, United States · NIH-11418068

• Low-dose colchicine for reducing vascular risk in people with PAD

  A large international study will test whether a daily low dose of colchicine can lower heart and limb-related risks for people with peripheral artery disease.

  NIH research Duke University · Durham, United States · NIH-11417947

• IMProving mobility After revasCularizaTion in Peripheral Artery Disease

  This study tests whether home-based exercise plus a nitrate supplement can help people with leg artery disease walk farther after a vascular procedure.

  NIH research Northwestern University · Chicago, United States · NIH-11404987

• Improving Mobility After Revascularization in Peripheral Artery Disease

  A data coordinating center plans to support a large multi-site trial that aims to improve mobility after revascularization in people with peripheral artery disease.

  NIH research Wake Forest University Health Sciences · Winston-Salem, United States · NIH-11404976

• Molecular imaging of artery disease in leg arteries

  A new imaging approach uses a special PET/CT scan to map blood flow and mineral buildup in leg arteries of people with PAD.

  NIH research Research Inst Nationwide Children's Hosp · Columbus, United States · NIH-11404971

• Low-dose colchicine for people with peripheral artery disease

  People with peripheral artery disease will take a daily low-dose colchicine pill or a placebo to see if it lowers their risk of heart attacks, strokes, and limb problems.

  NIH research Duke University · Durham, United States · NIH-11399633

• Artificial intelligence to detect peripheral artery disease early

  A hospital-based project uses AI to spot peripheral artery disease early in adults using electronic health records so clinicians can start care sooner.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11394514

• Non-Ischemic, pain-free exercise for peripheral artery disease

  A patient-friendly exercise program that avoids leg ischemia is being tested to help people with peripheral artery disease walk farther and feel better.

  NIH research University of Oklahoma Hlth Sciences Ctr · Oklahoma City, United States · NIH-11393017

• Exercise-driven reflex and blood flow in leg disease: flow limits and reperfusion

  In people with peripheral artery disease, we’re studying why exercise makes blood pressure rise and how to make walking easier by blocking a specific nerve-sensing channel.

  NIH research Pennsylvania State Univ Hershey Med Ctr · Hershey, United States · NIH-11378471

• Diet and exercise plan to help people with peripheral artery disease (PAD)

  A modified DASH diet plus a regular exercise program is studied to help older adults with PAD walk longer, feel better, and have healthier blood vessels.

  NIH research University of Oklahoma Hlth Sciences Ctr · Oklahoma City, United States · NIH-11378395

• Personalized prevention of blood clots after artery procedures in older adults

  A study tests tailored blood-thinning strategies for people 65 and older who had artery repair to prevent dangerous clots and possible amputation.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11364022

• Low-dose colchicine for peripheral artery disease to lower vascular risk

  People with peripheral artery disease will take a daily low-dose colchicine pill or a matching placebo to try to reduce heart attacks, strokes, and limb complications.

  NIH research Duke University · Durham, United States · NIH-11328633

• Home-based walking program for veterans with PAD using telehealth

  A telehealth-based walking program is being tested to help veterans with peripheral artery disease improve activity and health at home.

  NIH research Birmingham VA Medical Center · Birmingham, United States · NIH-11327218

• Peripheral Artery Disease: Long-term Survival and Outcomes (PEARLS)

  A national study using advanced data tools to understand how people with peripheral artery disease fare over many years, including survival, heart events, and limb outcomes.

  NIH research Ut Southwestern Medical Center · Dallas, United States · NIH-11326834

• Warm-leg therapy to help people with peripheral artery disease walk and do more

  This project tests whether wearing portable, hot-water circulating trousers at home can improve walking, leg strength, and daily life for people with peripheral artery disease.

  NIH research Purdue University · West Lafayette, United States · NIH-11323098

• Novel at-home leg heat therapy device to improve mobility in PAD

  A new at-home device delivers leg heat therapy to help people with peripheral artery disease walk farther and feel stronger without the pain of traditional gym programs.

  NIH research Aquilo Sports, LLC · Louisville, United States · NIH-11313575

• Improved Sirolimus-Analog Adventitial Delivery for Below-the-Knee PAD

  A new sirolimus-like drug delivery method targeting the artery outer layer aims to improve blood flow and limb outcomes for people with below-the-knee peripheral artery disease.

  NIH research Mercator Medsystems, INC. · San Leandro, UNITED STATES · NIH-11299471

• Stopping calcium buildup in leg arteries

  This project will look at whether boosting CD73-driven adenosine signaling can reduce harmful calcium buildup in the leg arteries of adults with peripheral artery disease.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11295422

• Radiotracer imaging to measure blood flow in leg muscles with peripheral artery disease

  Using special radioactive scans to make pictures of blood flow in the leg muscles of people with peripheral artery disease.

  NIH research Research Inst Nationwide Children's Hosp · Columbus, United States · NIH-11252177

• Dual-tracer PET/CT scans to image blood flow and nerve activity in diabetic leg disease

  This work uses two PET tracers to take detailed pictures of blood flow and nerve signals in people with diabetes who have or are at risk for peripheral artery disease.

  NIH research Yale University · New Haven, United States · NIH-11238505

• Imaging techniques for understanding blood flow issues in diabetic patients

  This study is looking at how diabetes impacts blood flow and nerve health in people with peripheral artery disease (PAD) by using special imaging to see what's happening in their legs, with the goal of finding better ways to manage and treat their condition.

  NIH research Yale University · New Haven, United States · NIH-11237395

• Better Ways to Find Peripheral Artery Disease in People with Kidney Disease

  This research aims to find more accurate ways to diagnose peripheral artery disease, a condition affecting blood flow to the limbs, in people who also have chronic kidney disease.

  NIH research Ut Southwestern Medical Center · Dallas, United States · NIH-11229401

• Peripheral Artery Disease pain care: how imaging, mind, and nerves shape better comfort

  Aims to combine new MRI ways to measure blood flow and tissue health with psychological and clinical factors to understand and reduce PAD pain.

  NIH research Yale University · New Haven, United States · NIH-11227963

• Investigating how microRNA-210 affects oxidative stress in patients with peripheral artery disease

  This study is looking at how a tiny molecule called microRNA-210 affects muscle health in people with peripheral artery disease (PAD) and how it might help doctors create better, personalized treatments for patients after they have surgery to improve blood flow.

  NIH research University of West Florida · Pensacola, United States · NIH-11220628

• Improving walking after leg artery revascularization

  This project checks whether adding a home-based walking program and nitrate-rich beetroot juice helps people with peripheral artery disease walk better after revascularization procedures.

  NIH research Northwestern University · Chicago, United States · NIH-11220054

• Improving PAD care with community screening and virtual management

  A program to screen people in communities for peripheral artery disease (PAD) and help newly diagnosed patients manage their care via a virtual platform.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11205128

• Low-dose colchicine for peripheral artery disease (LEADER-PAD)

  People with peripheral artery disease will take a low daily dose of colchicine or a placebo to try to lower the chance of heart attacks, strokes, and limb problems.

  NIH research Duke University · Durham, United States · NIH-11197610

• Helping people walk better after leg artery procedures

  This project runs a trial comparing two ways to help people with peripheral artery disease walk better after procedures that open blocked leg arteries.

  NIH research Wake Forest University Health Sciences · Winston-Salem, United States · NIH-11193863

• AI to spot peripheral artery disease sooner

  This project tests an AI tool that scans health records to find early signs of peripheral artery disease in adults.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11179489

• Pain-free walking program for people with peripheral artery disease

  This project will compare a gentle, pain-free walking program to standard painful exercise to see if it helps older adults with peripheral artery disease walk farther and feel better.

  NIH research University of Oklahoma Hlth Sciences Ctr · Oklahoma City, United States · NIH-11178340

• Understanding Exercise Discomfort in Peripheral Artery Disease

  This project looks at why exercise can be painful for people with peripheral artery disease and explores ways to make it easier.

  NIH research Pennsylvania State Univ Hershey Med Ctr · Hershey, United States · NIH-11127625

• Understanding long-term survival and outcomes in patients with peripheral artery disease.

  This study is looking at how well different treatments work for people with peripheral artery disease (PAD) over time, especially focusing on veterans, to help improve their health and understand any differences in care based on race and ethnicity.

  NIH research Ut Southwestern Medical Center · Dallas, United States · NIH-11127453

• Improving Walking and Health for Peripheral Artery Disease

  This research looks at whether a special diet combined with exercise can help people with peripheral artery disease walk better and feel healthier.

  NIH research University of Oklahoma Hlth Sciences Ctr · Oklahoma City, United States · NIH-11109455

• Using leg heat therapy to help people with peripheral artery disease improve their physical performance

  This study is looking at how wearing special heated trousers at home can help people with peripheral artery disease (PAD) feel better and move more easily by improving blood flow and muscle strength.

  NIH research Purdue University · West Lafayette, United States · NIH-11083011

• Using big data to find better treatments for peripheral artery disease in patients with chronic kidney disease

  This study is looking at how we can use large amounts of health data to find better treatments for people with peripheral artery disease (PAD) who also have chronic kidney disease (CKD), aiming to improve their care and reduce risks like amputation.

  NIH research Stanford University · Stanford, United States · NIH-11045010

• Investigating the role of arterial calcification in peripheral artery disease

  This study is looking at how a specific type of artery hardening called medial arterial calcification (MAC) affects people with peripheral artery disease (PAD), and it aims to find out how a certain enzyme might help us understand and treat this condition better.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11021469

Related topics

Quick answers

How many Peripheral Artery Disease clinical trials are recruiting right now?

42, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 16 countries. The most sites are in United States (20 trials), France (4 trials), China (4 trials), South Korea (3 trials), Singapore (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 3: 3, Phase 2: 1, Early Phase 1: 1, Phase 4: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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