Investigating the role of arterial calcification in peripheral artery disease
Medial Arterial Calcification in Peripheral Artery Disease
This study is looking at how a specific type of artery hardening called medial arterial calcification (MAC) affects people with peripheral artery disease (PAD), and it aims to find out how a certain enzyme might help us understand and treat this condition better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-11021469 on NIH RePORTER |
What this research studies
This research focuses on understanding medial arterial calcification (MAC) in patients with peripheral artery disease (PAD), particularly how it differs from traditional atherosclerosis. The study aims to explore the mechanisms behind MAC, including the role of the enzyme CD73 and its product, adenosine, in vascular health. By examining the relationship between CD73 levels and MAC, the research seeks to identify potential therapeutic targets to improve patient outcomes. Patients may be involved in assessments that help clarify the pathogenesis of this condition.
Who could benefit from this research
Good fit: Ideal candidates for participation include adults diagnosed with peripheral artery disease, particularly those exhibiting symptoms of medial arterial calcification.
Not a fit: Patients with peripheral artery disease who do not have any signs of medial arterial calcification may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve vascular health and reduce complications associated with peripheral artery disease.
How similar studies have performed: While the investigation of medial arterial calcification is emerging, previous studies have shown promising results in understanding related mechanisms in vascular diseases.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: St. Hilaire, Cynthia — University of Pittsburgh at Pittsburgh
- Study coordinator: St. Hilaire, Cynthia
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.