Investigating the role of arterial calcification in peripheral artery disease
Official title: Medial Arterial Calcification in Peripheral Artery Disease
Funded at University of Pittsburgh at Pittsburgh · NIH-11021469 · Data updated 2026-11-12
This study is looking at how a specific type of artery hardening called medial arterial calcification (MAC) affects people with peripheral artery disease (PAD), and it aims to find out how a certain enzyme might help us understand and treat this condition better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project start | March 5, 2025 |
| Project end | December 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $761,042 |
| NIH project number | 1R01HL176595-01 |
| Project ID | NIH-11021469 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation include adults diagnosed with peripheral artery disease, particularly those exhibiting symptoms of medial arterial calcification.
✕Less likely to help
Patients with peripheral artery disease who do not have any signs of medial arterial calcification may not benefit from this research.
What this research studies
This research focuses on understanding medial arterial calcification (MAC) in patients with peripheral artery disease (PAD), particularly how it differs from traditional atherosclerosis. The study aims to explore the mechanisms behind MAC, including the role of the enzyme CD73 and its product, adenosine, in vascular health. By examining the relationship between CD73 levels and MAC, the research seeks to identify potential therapeutic targets to improve patient outcomes. Patients may be involved in assessments that help clarify the pathogenesis of this condition.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve vascular health and reduce complications associated with peripheral artery disease.
How similar studies have gone: While the investigation of medial arterial calcification is emerging, previous studies have shown promising results in understanding related mechanisms in vascular diseases.
Where this research is happening
-
University of Pittsburgh at Pittsburgh
Pittsburgh, United States Active
Researchers
- Principal investigator: St. Hilaire, Cynthia — University of Pittsburgh at Pittsburgh
- Study coordinator: St. Hilaire, Cynthia
Related research
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-
Low-dose colchicine for reducing vascular risk in people with PAD
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.