IMProving mobility After revasCularizaTion in Peripheral Artery Disease
Official title: IMProving mobility After revasCularizaTion in Peripheral Artery Disease: the IMPACT PAD Trial
Funded at Northwestern University · NIH-11404987 · Data updated 2026-11-12
This study tests whether home-based exercise plus a nitrate supplement can help people with leg artery disease walk farther after a vascular procedure.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northwestern University NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | September 17, 2024 |
| Project end | August 31, 2031 |
| Funding year | 2026 |
| Award (this year) | $1,379,953 |
| NIH project number | 5UH3HL169565-03 |
| Project ID | NIH-11404987 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with PAD who are undergoing lower-extremity revascularization for disabling symptoms and who can participate in a home-based exercise program.
✕Less likely to help
Patients unable to participate in home-based exercise or sensitive to nitrate supplements may see no additional benefit.
What this research studies
People with peripheral artery disease often undergo revascularization to improve walking, but gains are not complete. This trial explores whether adding a home-based exercise plan after revascularization can add to the benefit, compared to revascularization alone. It also tests whether a nitrate source, like beetroot juice, can further boost walking performance compared with placebo. The plan combines clinical procedures, home exercise, and a simple dietary supplement to see if daily habits can strengthen recovery and mobility.
Why it matters
Potential benefit: If successful, patients may walk farther and experience less disability after revascularization.
How similar studies have gone: Previous work suggests exercise and nitrate supplementation can improve walking in PAD, but this specific combination after revascularization is being tested.
Where this research is happening
-
Northwestern University
Chicago, United States Active
Researchers
- Principal investigator: Mcdermott, Mary Mcgrae — Northwestern University
- Study coordinator: Mcdermott, Mary Mcgrae
Related research
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Low-dose colchicine for reducing vascular risk in people with PAD
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.