Understanding long-term survival and outcomes in patients with peripheral artery disease.
Official title: Peripheral Artery Disease: Long-term Survival & Outcomes Study (PEARLS)
Funded at Ut Southwestern Medical Center · NIH-11127453 · Data updated 2026-11-12
This study is looking at how well different treatments work for people with peripheral artery disease (PAD) over time, especially focusing on veterans, to help improve their health and understand any differences in care based on race and ethnicity.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project start | July 1, 2023 |
| Project end | April 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $557,403 |
| NIH project number | 5R01HL166305-03 |
| Project ID | NIH-11127453 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are veterans diagnosed with peripheral artery disease, particularly those experiencing significant cardiovascular risks or mobility issues.
✕Less likely to help
Patients without a diagnosis of peripheral artery disease or those who are not veterans may not benefit from this research.
What this research studies
This research investigates the long-term survival and clinical outcomes of patients with peripheral artery disease (PAD), a condition that significantly impacts mobility and increases the risk of cardiovascular events. By utilizing advanced natural language processing techniques, the study aims to accurately identify PAD patients within the Veterans Health Administration. The research will evaluate the effectiveness of various treatments and explore disparities in care based on race and ethnicity. Ultimately, the goal is to fill critical gaps in knowledge regarding PAD and improve patient outcomes.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies and better management of peripheral artery disease, enhancing the quality of life for patients.
How similar studies have gone: Previous research has shown success in using big data analytics and natural language processing to improve patient identification and outcomes in various medical conditions, suggesting a promising approach for this study.
Where this research is happening
-
Ut Southwestern Medical Center
Dallas, United States Active
Researchers
- Principal investigator: Girotra, Saket — Ut Southwestern Medical Center
- Study coordinator: Girotra, Saket
Related research
Other NIH-funded projects on the same topics.
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Low-dose colchicine to reduce vascular risk in people with peripheral artery disease
This project tests whether taking a low-dose anti-inflammatory drug (colchicine) daily can lower heart and limb-related risks for adults with peripheral artery disease.
-
Gamified home walking program to help seniors with peripheral artery disease improve walking and quality of life
A program uses game elements on wearable devices to help people 65+ with peripheral artery disease walk more at home and feel better.
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Fatty clues in leg arteries: how fat burning in mitochondria affects PAD and muscle health
This project looks at how fat metabolism in leg muscles relates to weakness and tissue damage in people with peripheral artery disease and aims to find new ways to help them.
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Enhancing muscle energy to help leg function in PAD
A study to boost how muscle mitochondria work in people with peripheral artery disease to improve walking and leg function.
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Low-dose colchicine for people with peripheral artery disease to reduce heart and limb risks
A large international study will test whether a low daily dose of colchicine can lower heart and limb complications for people with peripheral artery disease.
-
Low-dose colchicine for reducing vascular risk in people with PAD
A large international study will test whether a daily low dose of colchicine can lower heart and limb-related risks for people with peripheral artery disease.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.