Personalized prevention of blood clots after artery procedures in older adults
Official title: Personalizing Post Surgical Thromboprophylaxis for Elderly Patients with Peripheral Artery Disease
Funded at Massachusetts General Hospital · NIH-11364022 · Data updated 2026-11-12
A study tests tailored blood-thinning strategies for people 65 and older who had artery repair to prevent dangerous clots and possible amputation.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | June 1, 2026 |
| Project end | May 31, 2031 |
| Funding year | 2026 |
| Award (this year) | $852,113 |
| NIH project number | 1R01AG094610-01A1 |
| Project ID | NIH-11364022 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are adults aged 65 and older who have PAD and are undergoing endovascular revascularization, including postmenopausal women.
✕Less likely to help
Some patients may not benefit if their clot risk is unrelated to the factors studied or if they have contraindications to antithrombotic therapies.
What this research studies
If you are 65 or older and have PAD that needed endovascular repair, this project looks at personalized ways to prevent clots after the procedure. The research builds on the TARGET protocol to tailor thromboprophylaxis, aiming to reduce the 20% clot rate within six months and improve survival and limb outcomes. The team will compare customized treatment plans to current standard care, with attention to differences by sex and menopause status. Participants may undergo specific risk assessments and receive adjusted antithrombotic therapies under close medical supervision. The goal is to make post-surgical care safer and more effective for older adults similar to you.
Why it matters
Potential benefit: If successful, this approach could lower clot risk, reduce amputations, and improve survival for older patients after arterial procedures.
How similar studies have gone: Previous pilot work with the TARGET protocol shows promise for individualized thromboprophylaxis in older patients undergoing arterial procedures.
Where this research is happening
-
Massachusetts General Hospital
Boston, United States Active
Researchers
- Principal investigator: Dua, Anahita — Massachusetts General Hospital
- Study coordinator: Dua, Anahita
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.