Improving Walking and Health for Peripheral Artery Disease
Official title: The Effects of Diet and Exercise Interventions in Peripheral Artery Disease
Funded at University of Oklahoma Hlth Sciences Ctr · NIH-11109455 · Data updated 2026-11-12
This research looks at whether a special diet combined with exercise can help people with peripheral artery disease walk better and feel healthier.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Oklahoma Hlth Sciences Ctr NIH-funded |
| Lab location | 1 site (Oklahoma City, United States) |
| Project start | September 1, 2022 |
| Project end | May 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $497,164 |
| NIH project number | 5R01AG070086-05 |
| Project ID | NIH-11109455 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this type of research would be individuals aged 65 or older who have peripheral artery disease with leg pain during walking (claudication).
✕Less likely to help
Patients who do not have peripheral artery disease or are unable to participate in diet and exercise programs may not receive direct benefit from this specific research.
What this research studies
We are exploring if a modified DASH eating plan, when added to a standard exercise program, can offer a better way to help patients with peripheral artery disease. Our goal is to see if this combined approach improves walking ability, how blood vessels in the legs work, and reduces inflammation. We believe this could lead to better overall health and quality of life for those living with this condition.
Why it matters
Potential benefit: If successful, this approach could provide patients with peripheral artery disease a more effective way to improve their walking, reduce inflammation, and enhance their overall quality of life.
How similar studies have gone: This research builds upon preliminary work that has already shown promise for a modified diet combined with exercise in patients with peripheral artery disease.
Where this research is happening
-
University of Oklahoma Hlth Sciences Ctr
Oklahoma City, United States Active
Researchers
- Principal investigator: Gardner, Andrew W — University of Oklahoma Hlth Sciences Ctr
- Study coordinator: Gardner, Andrew W
Related research
Other NIH-funded projects on the same topics.
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Low-dose colchicine to reduce vascular risk in people with peripheral artery disease
This project tests whether taking a low-dose anti-inflammatory drug (colchicine) daily can lower heart and limb-related risks for adults with peripheral artery disease.
-
Gamified home walking program to help seniors with peripheral artery disease improve walking and quality of life
A program uses game elements on wearable devices to help people 65+ with peripheral artery disease walk more at home and feel better.
-
Fatty clues in leg arteries: how fat burning in mitochondria affects PAD and muscle health
This project looks at how fat metabolism in leg muscles relates to weakness and tissue damage in people with peripheral artery disease and aims to find new ways to help them.
-
Enhancing muscle energy to help leg function in PAD
A study to boost how muscle mitochondria work in people with peripheral artery disease to improve walking and leg function.
-
Low-dose colchicine for people with peripheral artery disease to reduce heart and limb risks
A large international study will test whether a low daily dose of colchicine can lower heart and limb complications for people with peripheral artery disease.
-
Low-dose colchicine for reducing vascular risk in people with PAD
A large international study will test whether a daily low dose of colchicine can lower heart and limb-related risks for people with peripheral artery disease.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.