Red light treatment for improving blood flow in peripheral artery disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the effects of a single 5-minute exposure to 670 nm red light on blood flow in the gastrocnemius muscle of patients diagnosed with peripheral artery disease. Participants will undergo blood flow measurement using contrast-enhanced ultrasound before and after the light exposure, along with blood samples collected to assess nitric oxide metabolites. The study aims to determine if this non-invasive treatment can enhance vasodilation and improve circulation in affected individuals. It is designed to be completed in one visit, with a possibility of a second visit if data quality requires it.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Participants will be subjects between the ages of 18 and 85 who have been diagnosed with peripheral artery disease. Men and women will be recruited for participation. All ethnicities will be included in this study.

Diagnosis of peripheral artery disease is defined as an Ankle Brachial index of \<0.9 or greater than 1.1 either at rest or during treadmill exercise.

Exclusion Criteria:

* Exclusionary criteria include age under 18 years and over 85 years, those who are unable to understand the consent process , those who cannot read or speak English, active pregnancy, hypersensitivity to perflutren contrast agents, pulmonary hypertension, active illicit drug use, untreated blood pressure over 160/95, sickle cell disease, or a history of intracardiac shunt. Additional exclusion criteria neurological diseases such as spinal stenosis, unspecified pain disorders, and any uncontrolled medical conditions.

Where it's running

• Medical College of Wisconsin
  Milwaukee, Wisconsin, United States Recruiting

Study contacts

• Principal investigator: Nicole L Lohr, MD,PHD — Medical College of Wisconsin
• Study coordinator: Nicole L Lohr, MD,PHD
• Email: nlohr@uabmc.edu
• Phone: 414-996-3504

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.