Helping people walk better after leg artery procedures
Official title: 2/2 Improving Mobility After Revascularization in Peripheral Artery Disease: The IMPACT PAD Trial
Funded at Wake Forest University Health Sciences · NIH-11193863 · Data updated 2026-11-12
This project runs a trial comparing two ways to help people with peripheral artery disease walk better after procedures that open blocked leg arteries.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Wake Forest University Health Sciences NIH-funded |
| Lab location | 1 site (Winston-Salem, United States) |
| Project start | September 17, 2024 |
| Project end | August 31, 2031 |
| Funding year | 2025 |
| Award (this year) | $618,504 |
| NIH project number | 5U24HL169563-02 |
| Project ID | NIH-11193863 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with peripheral artery disease who have recently undergone revascularization for blocked leg arteries and who have trouble walking are the ideal candidates.
✕Less likely to help
People without peripheral artery disease, those who have not had revascularization, or those whose mobility problems are caused by non-vascular issues are unlikely to benefit from this trial.
What this research studies
The main trial will enroll about 386 people who have peripheral artery disease and recently had revascularization to improve leg blood flow, using a 2×2 design to compare combined approaches. Wake Forest will serve as the data coordinating center that organizes the study across multiple clinical sites, manages data, and supports the statistical and operational needs. The team will work with site investigators and a safety monitoring committee to ensure consistent treatment, high-quality follow-up, and participant safety. If you join, your health, walking ability, and outcomes will be tracked carefully across the participating centers.
Why it matters
Potential benefit: If successful, the results could help people regain walking ability faster and reduce leg symptoms after revascularization for peripheral artery disease.
How similar studies have gone: Previous trials have shown some rehabilitation and medical strategies can improve walking after PAD, but using a 2×2 factorial design to compare combined approaches is less commonly tested.
Where this research is happening
-
Wake Forest University Health Sciences
Winston-Salem, United States Active
Researchers
- Principal investigator: Ambrosius, Walter T — Wake Forest University Health Sciences
- Study coordinator: Ambrosius, Walter T
Related research
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Low-dose colchicine for reducing vascular risk in people with PAD
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.