Better Ways to Find Peripheral Artery Disease in People with Kidney Disease
Official title: Establishing A New Diagnostic Paradigm for Peripheral Artery Disease among Patients with Chronic Kidney Disease
Funded at Ut Southwestern Medical Center · NIH-11229401 · Data updated 2026-11-12
This research aims to find more accurate ways to diagnose peripheral artery disease, a condition affecting blood flow to the limbs, in people who also have chronic kidney disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project start | August 15, 2021 |
| Project end | July 31, 2026 |
| Funding year | 2023 |
| Award (this year) | $335,000 |
| NIH project number | 7R01HL157903-04 |
| Project ID | NIH-11229401 on NIH RePORTER |
Who could benefit from this research
✓Could help
This research is relevant for patients living with chronic kidney disease who are at risk for or have symptoms of peripheral artery disease.
✕Less likely to help
Patients without chronic kidney disease or peripheral artery disease may not directly benefit from this specific diagnostic improvement.
What this research studies
Peripheral artery disease (PAD) is common and more serious for people with chronic kidney disease (CKD), but current diagnostic tests like the ankle-brachial index (ABI) can be misleading due to stiff arteries. We know that both very low and very high ABI readings in CKD patients are linked to worse outcomes, and our early work suggests current diagnostic cut-offs don't always catch PAD accurately. This project will look for new, more precise ways to use ABI and toe-brachial index (TBI) measurements, along with other health factors, to better identify PAD in people with kidney disease. Our goal is to develop improved diagnostic tools that can lead to earlier and more effective treatment.
Why it matters
Potential benefit: If successful, this work could lead to earlier and more accurate diagnosis of peripheral artery disease in patients with chronic kidney disease, potentially preventing serious complications like amputation.
How similar studies have gone: Previous studies by this team have shown that current diagnostic methods for PAD are often inaccurate in CKD patients, suggesting a need for these novel approaches.
Where this research is happening
-
Ut Southwestern Medical Center
Dallas, United States Active
Researchers
- Principal investigator: Chen, Jing — Ut Southwestern Medical Center
- Study coordinator: Chen, Jing
Related research
Other NIH-funded projects on the same topics.
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Using big data to find better treatments for peripheral artery disease in patients with chronic kidney disease
This study is looking at how we can use large amounts of health data to find better treatments for people with peripheral artery disease (PAD) who also have chronic kidney disease (CKD), aiming to improve their care and reduce risks like amputation.
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Improving diagnosis of peripheral artery disease in patients with chronic kidney disease
This study is looking to improve how we diagnose peripheral artery disease (PAD) in people who also have chronic kidney disease (CKD), by testing new ways to measure blood flow that might work better for them.
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Personalized CKD-MBD care using systems biology and AI
A patient-facing program aims to tailor mineral-balance therapy for people with chronic kidney disease by using a computer model and smart decision rules to predict who will respond best to treatments.
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Mitigating DKA in people with type 1 diabetes and kidney disease using SGLT1/2 inhibitors
This project tests a new way to prevent dangerous diabetic ketoacidosis in people with type 1 diabetes and chronic kidney disease who are using SGLT inhibitors, by tracking ketones in real time and combining glucose-keton data for safer therapy.
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Chronic Kidney Disease in Children: following young people as they grow up with CKD
A long-term study in kids with chronic kidney disease tracks kidney function and heart health as they transition into adulthood.
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Chronic Kidney Disease in Children follow-up study
A long-term study that follows kids with kidney disease as they grow into young adults, collecting health data from home and official records.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.