Better Ways to Find Peripheral Artery Disease in People with Kidney Disease
Establishing A New Diagnostic Paradigm for Peripheral Artery Disease among Patients with Chronic Kidney Disease
This research aims to find more accurate ways to diagnose peripheral artery disease, a condition affecting blood flow to the limbs, in people who also have chronic kidney disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project ID | NIH-11229401 on NIH RePORTER |
What this research studies
Peripheral artery disease (PAD) is common and more serious for people with chronic kidney disease (CKD), but current diagnostic tests like the ankle-brachial index (ABI) can be misleading due to stiff arteries. We know that both very low and very high ABI readings in CKD patients are linked to worse outcomes, and our early work suggests current diagnostic cut-offs don't always catch PAD accurately. This project will look for new, more precise ways to use ABI and toe-brachial index (TBI) measurements, along with other health factors, to better identify PAD in people with kidney disease. Our goal is to develop improved diagnostic tools that can lead to earlier and more effective treatment.
Who could benefit from this research
Good fit: This research is relevant for patients living with chronic kidney disease who are at risk for or have symptoms of peripheral artery disease.
Not a fit: Patients without chronic kidney disease or peripheral artery disease may not directly benefit from this specific diagnostic improvement.
Why it matters
Potential benefit: If successful, this work could lead to earlier and more accurate diagnosis of peripheral artery disease in patients with chronic kidney disease, potentially preventing serious complications like amputation.
How similar studies have performed: Previous studies by this team have shown that current diagnostic methods for PAD are often inaccurate in CKD patients, suggesting a need for these novel approaches.
Where this research is happening
Dallas, United States
- Ut Southwestern Medical Center — Dallas, United States (Active)
Researchers
- Principal investigator: Chen, Jing — Ut Southwestern Medical Center
- Study coordinator: Chen, Jing
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.