Improving walking after leg artery revascularization
IMProving mobility After revasCularizaTion in Peripheral Artery Disease: the IMPACT PAD Trial
This project checks whether adding a home-based walking program and nitrate-rich beetroot juice helps people with peripheral artery disease walk better after revascularization procedures.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northwestern University NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project ID | NIH-11220054 on NIH RePORTER |
What this research studies
If you join after a lower-extremity revascularization, the study will compare usual post-procedure care to a program that adds guided home-based walking therapy. At the same time, participants will be assigned to take either inorganic nitrate (from beetroot juice) or a placebo to see if the supplement boosts recovery. Researchers will measure walking ability with standardized walking tests and follow participants at scheduled clinic visits. The goal is to find an accessible way to improve walking without requiring supervised exercise programs.
Who could benefit from this research
Good fit: People with peripheral artery disease who are scheduled for or have recently undergone lower-extremity revascularization for disabling but non-limb-threatening blockages are the intended participants.
Not a fit: People with limb-threatening ischemia, those who cannot safely walk or follow a home exercise program, or those with medical contraindications to nitrates may not be eligible or receive benefit.
Why it matters
Potential benefit: If successful, this approach could help people walk farther and recover better after leg artery procedures using an accessible home rehabilitation program and a simple dietary supplement.
How similar studies have performed: Previous trials show supervised exercise plus revascularization improves walking, but combining home-based exercise and nitrate supplementation after revascularization is a relatively new approach.
Where this research is happening
Chicago, United States
- Northwestern University — Chicago, United States (Active)
Researchers
- Principal investigator: Mcdermott, Mary Mcgrae — Northwestern University
- Study coordinator: Mcdermott, Mary Mcgrae
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.