Peripheral Artery Disease: Long-term Survival and Outcomes (PEARLS)
Official title: Peripheral Artery Disease: Long-term Survival & Outcomes Study (PEARLS)
Funded at Ut Southwestern Medical Center · NIH-11326834 · Data updated 2026-11-12
A national study using advanced data tools to understand how people with peripheral artery disease fare over many years, including survival, heart events, and limb outcomes.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project start | July 1, 2023 |
| Project end | April 30, 2027 |
| Funding year | 2026 |
| Award (this year) | $606,950 |
| NIH project number | 5R01HL166305-04 |
| Project ID | NIH-11326834 on NIH RePORTER |
Who could benefit from this research
✓Could help
Veterans with diagnosed peripheral artery disease who can have their medical records analyzed using NLP methods.
✕Less likely to help
Patients whose PAD is not captured well by current records or who are outside the Veterans Health Administration may see limited direct benefit.
What this research studies
This project will identify people with PAD in the Veterans Health Administration using an innovative natural language processing method. It will follow patients over time to see who develops heart attacks, strokes, or limb complications, and how treatments influence these outcomes. The team will also examine whether race or ethnicity affects access to high-quality care and the resulting health results. Findings could inform safer, more effective care plans to improve both survival and limb health for PAD patients.
Why it matters
Potential benefit: If successful, the study could lead to better prediction of risks and more equitable, evidence-based care for people with PAD.
How similar studies have gone: Preliminary NLP approaches have shown promise in correctly identifying PAD patients in large health systems, suggesting potential for meaningful insights from this study.
Where this research is happening
-
Ut Southwestern Medical Center
Dallas, United States Active
Researchers
- Principal investigator: Girotra, Saket — Ut Southwestern Medical Center
- Study coordinator: Girotra, Saket
Related research
Other NIH-funded projects on the same topics.
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Low-dose colchicine to reduce vascular risk in people with peripheral artery disease
This project tests whether taking a low-dose anti-inflammatory drug (colchicine) daily can lower heart and limb-related risks for adults with peripheral artery disease.
-
Gamified home walking program to help seniors with peripheral artery disease improve walking and quality of life
A program uses game elements on wearable devices to help people 65+ with peripheral artery disease walk more at home and feel better.
-
Fatty clues in leg arteries: how fat burning in mitochondria affects PAD and muscle health
This project looks at how fat metabolism in leg muscles relates to weakness and tissue damage in people with peripheral artery disease and aims to find new ways to help them.
-
Enhancing muscle energy to help leg function in PAD
A study to boost how muscle mitochondria work in people with peripheral artery disease to improve walking and leg function.
-
Low-dose colchicine for people with peripheral artery disease to reduce heart and limb risks
A large international study will test whether a low daily dose of colchicine can lower heart and limb complications for people with peripheral artery disease.
-
Low-dose colchicine for reducing vascular risk in people with PAD
A large international study will test whether a daily low dose of colchicine can lower heart and limb-related risks for people with peripheral artery disease.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.