Condition

Metabolic Dysfunction-Associated Steatohepatitis clinical trials and research

• 14Clinical trials
• 3NIH research projects
• 1New in 30 days
• 37Countries

Newest Metabolic Dysfunction-Associated Steatohepatitis clinical trials

All recruiting trials (14)

• Endohepatology-based reclassification of treatment indication in high-risk MASLD

  This study tests whether an endohepatology assessment can change treatment decisions for adults with high-risk MASLD.

  Recruiting University Hospital Muenster · Münster · NCT07877272

• Pre-hepatectomy rehabilitation with mazdutide for obese MASLD donors

  This trial tests whether adding mazdutide to a structured lifestyle plan helps overweight MASLD donors lose liver fat faster to become eligible for donation.

  Recruiting Phase 4 West China Hospital · Hefei, Anhui and 3 other locations · NCT07718126

• Efimosfermin vs. placebo in adults with compensated cirrhosis from MASH

  This study tests whether Efimosfermin can help adults with compensated cirrhosis due to MASH compared with placebo.

  Recruiting at 35 sites Phase 3 GlaxoSmithKline · Little Rock, Arkansas and 34 other locations · NCT07704892

• Efimosfermin vs placebo in adults with compensated cirrhosis from MASH

  This study tests whether efimosfermin helps adults with compensated cirrhosis caused by MASH compared with placebo.

  Recruiting at 30 sites Phase 3 GlaxoSmithKline · Little Rock, Arkansas and 29 other locations · NCT07701993

• ALN-CIDEB for adults with fibrotic MASH (phase 2)

  This phase 2 study tests ALN-CIDEB versus placebo to see if it can reduce liver fat, injury, and scarring in adults with fibrotic MASH.

  Recruiting at 24 sites Phase 2 Regeneron Pharmaceuticals · Tucson, Arizona and 23 other locations · NCT07631637

• How food affects ECC4703 and how different formulations are absorbed in healthy adults.

  This trial will test how eating and different pill formulations change how ECC4703 is absorbed in healthy adults.

  Recruiting Phase 1 Eccogene · Adelaide, South Australia · NCT07334080

• Two experimental medicines, alone and together, for metabolic dysfunction-associated steatohepatitis (MASH)

  This trial will test whether two experimental drugs (ECC4703 and ECC0509), given alone or together, reduce liver fat in adults with metabolic dysfunction-associated steatohepatitis (MASH).

  Recruiting at 67 sites Phase 2 Eccogene · Chandler, Arizona and 69 other locations · NCT07288138

• Evaluating efimosfermin for patients with compensated cirrhosis and metabolic dysfunction

  This study is testing if a new treatment called efimosfermin can help people with compensated cirrhosis and metabolic dysfunction feel better and improve their liver health.

  Recruiting at 30 sites Phase 2 GlaxoSmithKline · Chandler, Arizona and 29 other locations · NCT06920043

• Link between MASH and mitochondrial membrane changes in people having bariatric surgery.

  We will test whether changes in mitochondria-associated membranes (MAMs) in liver cells and blood immune cells are linked to MASH in adults undergoing bariatric surgery.

  Recruiting at 2 sites Hospices Civils de Lyon · Lyon, France and 1 other locations · NCT06868992

• Identifying Prognostic Factors for Liver Disease and Transplant Needs

  This study is trying to find out which factors can help predict if people with certain liver diseases will need a transplant or develop liver cancer.

  Recruiting IRCCS Azienda Ospedaliero-Universitaria di Bologna · Bologna, Bologna · NCT06813508

• Testing Survodutide for Liver Disease in Patients with Cirrhosis

  This study is testing if a new medication called survodutide can help improve liver function in adults with cirrhosis caused by liver fat buildup.

  Recruiting at 429 sites Phase 3 Boehringer Ingelheim · Peoria, Arizona and 446 other locations · NCT06632457

• Testing the safety and tolerability of BI 3804379 in healthy individuals

  This study is testing a new drug called BI 3804379 in healthy men and women to see if it's safe and how well their bodies handle it.

  Recruiting Phase 1 Boehringer Ingelheim · Edegem · NCT06575400

• Endoscopic sleeve gastroplasty for people with obesity and MASH

  This study will test whether endoscopic sleeve gastroplasty plus lifestyle changes helps adults with obesity and MASH lose weight and improve liver health compared with lifestyle changes alone.

  Recruiting at 2 sites Brigham and Women's Hospital · Boston, Massachusetts and 1 other locations · NCT06138821

• Testing INI-822 in healthy volunteers and patients with NASH

  This study is testing a new treatment called INI-822 in healthy people and those with NASH to see how safe it is and how it affects the body.

  Recruiting at 12 sites Phase 1 Inipharm Australia Pty Ltd · Camperdown, New South Wales and 11 other locations · NCT05945537

NIH-funded research (3)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Regulation of ROBO1 by YAP and LHX2 in MASLD-related liver disease

  A study at Tulane is exploring how certain cell signals influence liver scarring and regeneration in fatty liver disease to find ways to reduce fibrosis.

  NIH research Tulane University of Louisiana · New Orleans, United States · NIH-11443482

• A new siRNA drug to treat fatty liver disease by boosting liver energy production

  A new siRNA drug aimed at reducing liver fat, inflammation, and fibrosis in people with metabolic dysfunction-associated steatohepatitis (MASH).

  NIH research Mitotherapeutix, LLC · Cheshire, United States · NIH-11312337

• Aldehydes and fat-related liver disease: how tiny molecules drive MASH in diabetes risk

  Aims to understand how aldehydes created in fatty liver may trigger liver damage and inflammation in people with obesity and type 2 diabetes.

  NIH research Medical University of South Carolina · Charleston, United States · NIH-11208763

Related topics

Quick answers

How many Metabolic Dysfunction-Associated Steatohepatitis clinical trials are recruiting right now?

14, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 37 countries. The most sites are in United States (6 trials), Australia (3 trials), Japan (3 trials), China (2 trials), France (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 3: 3, Phase 1: 3, Phase 2: 3, Phase 4: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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