Assessing the prevalence of Non-Alcoholic Fatty Liver Disease in adults
Official title: The Olmsted NAFLD Epidemiology Study (TONES)
Run by Mayo Clinic · NCT04365855 · Data updated 2026-11-12
This study is trying to find out how common Non-Alcoholic Fatty Liver Disease is among adults in Olmsted County, Minnesota, to help improve early diagnosis and treatment options.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 800 (estimated) |
| Sponsor | Mayo Clinic Academic / other |
| Locations | 1 site (Rochester, Minnesota) |
| Status | Recruiting |
| Started | October 10, 2020 |
| Main results expected | June 2028 |
| Study ends | June 2028 |
| Registry record updated | January 16, 2026 |
| Trial ID | NCT04365855 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults aged 18 or older residing in Olmsted County with no prior diagnosis of NAFLD.
✕Probably not a fit
Patients with a history of excessive alcohol consumption or contraindications to MRI may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study focuses on understanding the prevalence of Non-Alcoholic Fatty Liver Disease (NAFLD) and Non-Alcoholic Steatohepatitis (NASH) within a population. Researchers will enroll a random sample of adults from Olmsted County, Minnesota, to create a well-characterized cohort for validating diagnostic models and determining long-term outcomes. The study employs various interventions, including Magnetic Resonance Elastography and liver biopsies, to gather comprehensive data on liver health. The ultimate goal is to develop effective screening strategies for early diagnosis and intervention.
Why it matters
Potential benefit: If successful, this study could lead to improved early diagnosis and treatment options for patients with liver disease.
How similar studies have gone: Other studies have shown success in using machine learning models for diagnosing liver diseases, indicating potential for this approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Olmsted County residents at the time of search * Age 18 or older * No personal history of NAFLD diagnosis (administrative codes) Exclusion Criteria: * Alcohol in excess (more than 20 gm per week in women and 30 gm per week in men) * Currently pregnant * Have contraindications to MRI (MRI incompatible implanted devices, severe claustrophobia)
Where it's running
-
Mayo Clinic in Rochester
Rochester, Minnesota, United States Recruiting
Study contacts
- Principal investigator: Alina M Allen, Md — Mayo Clinic
- Study coordinator: Jodie A Cogswell
- Email: cogswell.jodie@mayo.edu
- Phone: 507-266-3995
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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This will test whether blood markers can detect liver scarring in adults with NAFLD or NASH who are having or recently had a liver biopsy.
-
Endoscopic sleeve gastroplasty for people with obesity and MASH
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-
Using endoscopic ultrasound to assess liver stiffness in patients with fatty liver disease
This study is testing if a special ultrasound can help find liver damage in people with fatty liver disease who are overweight, comparing it to other methods to see which works best.
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Understanding liver disease linked to alcohol and metabolic syndrome
This study is trying to find out what causes liver cancer in people with alcohol-related liver disease and fatty liver disease by looking at their health, diet, and immune system over several years.
-
Effect of a fibre supplement on children with fatty liver disease
This study is testing whether a fiber supplement can help children aged 8-17 with fatty liver disease improve their liver health over six months.
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This study is trying to collect samples and health information from people at higher risk of cancer to see if they can find signs that help predict cancer early on.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.