Clinical trial Recruiting at 1 site Interventional Ages 18 and up

Assessing the prevalence of Non-Alcoholic Fatty Liver Disease in adults

Official title: The Olmsted NAFLD Epidemiology Study (TONES)

Run by Mayo Clinic · NCT04365855 · Data updated 2026-11-12

This study is trying to find out how common Non-Alcoholic Fatty Liver Disease is among adults in Olmsted County, Minnesota, to help improve early diagnosis and treatment options.

More Non-Alcoholic Fatty Liver Disease trials

Quick facts

Study typeInterventional
Ages18 Years and up
SexAll
Enrollment800 (estimated)
SponsorMayo Clinic
Academic / other
Locations1 site (Rochester, Minnesota)
StatusRecruiting
StartedOctober 10, 2020
Main results expectedJune 2028
Study endsJune 2028
Registry record updatedJanuary 16, 2026
Trial IDNCT04365855 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are adults aged 18 or older residing in Olmsted County with no prior diagnosis of NAFLD.

Probably not a fit

Patients with a history of excessive alcohol consumption or contraindications to MRI may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study focuses on understanding the prevalence of Non-Alcoholic Fatty Liver Disease (NAFLD) and Non-Alcoholic Steatohepatitis (NASH) within a population. Researchers will enroll a random sample of adults from Olmsted County, Minnesota, to create a well-characterized cohort for validating diagnostic models and determining long-term outcomes. The study employs various interventions, including Magnetic Resonance Elastography and liver biopsies, to gather comprehensive data on liver health. The ultimate goal is to develop effective screening strategies for early diagnosis and intervention.

Why it matters

Potential benefit: If successful, this study could lead to improved early diagnosis and treatment options for patients with liver disease.

How similar studies have gone: Other studies have shown success in using machine learning models for diagnosing liver diseases, indicating potential for this approach.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Olmsted County residents at the time of search
* Age 18 or older
* No personal history of NAFLD diagnosis (administrative codes)

Exclusion Criteria:

* Alcohol in excess (more than 20 gm per week in women and 30 gm per week in men)
* Currently pregnant
* Have contraindications to MRI (MRI incompatible implanted devices, severe claustrophobia)

Where it's running

  • Mayo Clinic in Rochester
    Rochester, Minnesota, United States
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.