Improving early diagnosis of liver disease using integrated diagnostics

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to enhance the early diagnosis of liver disease by integrating data from patients with liver conditions, novel blood biomarkers, single nucleotide polymorphism (SNP) analysis, and fecal microbiome analysis. The study will assess patients referred to Community Liver Assessment Clinics (CLAC) to create a comprehensive database that combines various diagnostic tools. By implementing this new assessment pathway, the investigators expect to reduce the number of patients needing secondary care while improving the identification of liver fibrosis. The study will involve approximately 750 patients annually, focusing on those with abnormal liver blood tests or at high risk for liver disease.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* All patients referred to Community Liver Assessment Clinic.
* Male or female \> 18 years of age.
* Females will be non-pregnant and non-lactating.

Exclusion Criteria:

* Age \< 18 years.
* Pregnancy/breast-feeding. Women of childbearing potential (not \>2 years post- menopausal and/or not surgically sterilised) must have a negative blood serum pregnancy test.
* Isolated bilirubinaemia.
* Known pre-existing liver disease.
* Acutely unwell.
* Suspected malignancy.

Where it's running

• Manchester University NHS Foundation Trust
  Manchester, Greater Manchester, United Kingdom Recruiting

Study contacts

• Principal investigator: Varinder Athwal — Manchester University NHS Foundation Trust/Manchester University
• Study coordinator: Varinder Athwal
• Email: Varinder.athwal@manchester.ac.uk
• Phone: 0161 291 5354

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.