Clinical trial Recruiting at 1 site Interventional Ages 65 to 75 Women only

Additive Physical Activity for Hypothyroidism in Older Women with Glaucoma and Fatty Liver

Official title: Additive Efficacy of Physical Activity Program in Hypthyroidism Elder Females With Glaucoma and Fatty Liver Issues

Run by Cairo University · NCT07599241 · Data updated 2026-11-12

We’re testing whether adding a treadmill-based exercise program to standard thyroid treatment helps improve health in older women who have subclinical hypothyroidism, glaucoma, and fatty liver.

More Non-Alcoholic Fatty Liver Disease trials

Quick facts

Study typeInterventional
Ages65 Years to 75 Years
SexWomen only
Enrollment40 (estimated)
SponsorCairo University
Academic / other
Locations1 site (Dokki, Giza Governorate)
StatusRecruiting
StartedMarch 15, 2026
Main results expectedDecember 15, 2026
Study endsDecember 15, 2026
Registry record updatedMay 20, 2026
Trial IDNCT07599241 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are elder female patients with subclinical hypothyroidism, diagnosed primary open-angle glaucoma with ocular hypertension, and non-alcoholic fatty liver disease, who can safely participate in a supervised treadmill program.

Probably not a fit

Patients without responsiveness to thyroid therapy or unable to safely engage in physical activity may observe no additional benefit.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional study will randomly assign 40 elder female participants with subclinical hypothyroidism, primary open-angle glaucoma, and non-alcoholic fatty liver disease to two groups. One group will receive levothyroxine plus a thrice-weekly treadmill physical activity program for six months, while the other group will receive levothyroxine alone. The trial aims to see if adding exercise provides additional benefits beyond standard thyroid treatment. Primary outcomes may include thyroid-related measures, eye health indicators, and liver-related status, analyzed in a neutral medical-journalism tone. The study is conducted at Cairo University in Dokki, Egypt, with Cairo University as lead sponsor.

Why it matters

Potential benefit: If successful, participants may experience improved thyroid control and potential benefits to eye and liver health from the combined treatment approach.

How similar studies have gone: There is limited prior evidence on adding structured exercise to thyroid therapy in this specific combination of conditions; the approach is relatively novel for this population.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* subclinical hypothrodism (significant form)
* primary opened angle gaulcoma in both eyes with ocular hypertension in both eyes )(high-tension typed glaucoma)
* fatty liver (non alcholic type)
* elder females

Exclusion Criteria:

* respiratory issues
* cardiac issues
* renal issues

Where it's running

  • Cairo University
    Dokki, Giza Governorate, Egypt
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.