Additive Physical Activity for Hypothyroidism in Older Women with Glaucoma and Fatty Liver
Official title: Additive Efficacy of Physical Activity Program in Hypthyroidism Elder Females With Glaucoma and Fatty Liver Issues
Run by Cairo University · NCT07599241 · Data updated 2026-11-12
We’re testing whether adding a treadmill-based exercise program to standard thyroid treatment helps improve health in older women who have subclinical hypothyroidism, glaucoma, and fatty liver.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 65 Years to 75 Years |
| Sex | Women only |
| Enrollment | 40 (estimated) |
| Sponsor | Cairo University Academic / other |
| Locations | 1 site (Dokki, Giza Governorate) |
| Status | Recruiting |
| Started | March 15, 2026 |
| Main results expected | December 15, 2026 |
| Study ends | December 15, 2026 |
| Registry record updated | May 20, 2026 |
| Trial ID | NCT07599241 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are elder female patients with subclinical hypothyroidism, diagnosed primary open-angle glaucoma with ocular hypertension, and non-alcoholic fatty liver disease, who can safely participate in a supervised treadmill program.
✕Probably not a fit
Patients without responsiveness to thyroid therapy or unable to safely engage in physical activity may observe no additional benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This interventional study will randomly assign 40 elder female participants with subclinical hypothyroidism, primary open-angle glaucoma, and non-alcoholic fatty liver disease to two groups. One group will receive levothyroxine plus a thrice-weekly treadmill physical activity program for six months, while the other group will receive levothyroxine alone. The trial aims to see if adding exercise provides additional benefits beyond standard thyroid treatment. Primary outcomes may include thyroid-related measures, eye health indicators, and liver-related status, analyzed in a neutral medical-journalism tone. The study is conducted at Cairo University in Dokki, Egypt, with Cairo University as lead sponsor.
Why it matters
Potential benefit: If successful, participants may experience improved thyroid control and potential benefits to eye and liver health from the combined treatment approach.
How similar studies have gone: There is limited prior evidence on adding structured exercise to thyroid therapy in this specific combination of conditions; the approach is relatively novel for this population.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * subclinical hypothrodism (significant form) * primary opened angle gaulcoma in both eyes with ocular hypertension in both eyes )(high-tension typed glaucoma) * fatty liver (non alcholic type) * elder females Exclusion Criteria: * respiratory issues * cardiac issues * renal issues
Where it's running
-
Cairo University
Dokki, Giza Governorate, Egypt Recruiting
Study contacts
- Principal investigator: Ali MA Ismail, lecturer — Cairo University
- Study coordinator: Ali MA Ismail, lecturer
- Email: ali.mohamed@pt.cu.edu.eg
- Phone: 01005154209
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
G01 Eye Drops for Glaucomatous Optic Neuropathy
This trial tests whether G01 Eye Drops can help people with open-angle glaucoma who also have optic nerve injury.
-
Physical activity program for women with PCOS and fatty pancreas plus subclinical hypothyroidism
A program of exercise is being tested to see if it helps women with PCOS who also have fatty pancreas and subclinical hypothyroidism, compared to usual care.
-
Lifestyle changes plus nightly CPAP for glaucoma in people with sleep apnea
This test checks whether adding a low-calorie diet and regular walking to nightly CPAP lowers eye pressure in people with high‑pressure open‑angle glaucoma who also have obstructive sleep apnea and obesity.
-
Lowering insulin to reduce liver fat production
This study will try a short course of diazoxide to lower insulin and see if it reduces the liver's creation of new fat in adults with obesity, insulin resistance, and MASLD.
-
Direct Selective Laser Trabeculoplasty to reduce glaucoma medications
This study will try Direct Selective Laser Trabeculoplasty (DSLT) to reduce the number of eye-drop medications in adults with medically controlled primary open-angle glaucoma or ocular hypertension.
-
Hexiris MIST device to lower eye pressure in people with primary open-angle glaucoma
This trial will test the Hexiris MIST device to see if it lowers eye pressure in adults 40 and older whose primary open-angle glaucoma isn’t controlled by eye drops.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.