Identifying liver disease-specific gut microbiomes
Official title: Exploration of Liver-gut Axis Through Identification of Liver Disease-specific Microbiome
Run by Chungnam National University Hospital · NCT06519162 · Data updated 2026-11-12
This study is trying to find out if certain gut bacteria are linked to chronic liver diseases in adults, including autoimmune hepatitis and primary biliary cholangitis, by analyzing blood and stool samples from patients and their household members.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 19 Years and up |
| Sex | All |
| Enrollment | 3000 (estimated) |
| Sponsor | Chungnam National University Hospital Academic / other |
| Locations | 1 site (Daejeon, Jung-gu) |
| Status | Recruiting |
| Started | July 8, 2024 |
| Main results expected | July 8, 2029 |
| Study ends | July 8, 2029 |
| Registry record updated | March 20, 2026 |
| Trial ID | NCT06519162 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include adults aged 19 and older diagnosed with autoimmune hepatitis, primary biliary cholangitis, primary sclerosing cholangitis, non-alcoholic fatty liver disease, or liver abscess.
✕Probably not a fit
Patients under the age of 19 or those who do not consent to participate will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to identify gut microbiomes specific to patients with chronic refractory liver diseases, including autoimmune hepatitis and primary biliary cholangitis. Participants aged 19 and older, along with their household members, will provide blood and stool samples for analysis. The study will focus on understanding the gut-liver axis and its role in the pathogenesis and progression of liver diseases. The research will be conducted at Chungnam National University Hospital.
Why it matters
Potential benefit: If successful, this study could lead to improved understanding and management of chronic liver diseases through microbiome-targeted therapies.
How similar studies have gone: While studies on the gut-liver axis are emerging, this specific approach to identifying liver disease-specific microbiomes is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adults aged 19 years and older diagnosed with autoimmune hepatitis, primary biliary cholangitis, primary sclerosing cholangitis, non-alcoholic fatty liver disease, or liver abscess, who have consented to participate in this study at Chungnam National University Hospital. * Adults aged 19 years and older, who are cohabitants of patients diagnosed with autoimmune hepatitis, primary biliary cholangitis, primary sclerosing cholangitis, non-alcoholic fatty liver disease, or liver abscess, and have consented to participate in this study at Chungnam National University Hospital. B. Exclusion Exclusion Criteria: * Individuals under the age of 19. * Patients or guardians who do not consent to participate in the study
Where it's running
-
Chungnam National University Hospita
Daejeon, Jung-gu, South Korea Recruiting
Study contacts
- Principal investigator: Hyuksoo Eun — Chungnam National University Hospital
- Study coordinator: Soon Ok Kim
- Email: dona3734@cnuh.co.kr
- Phone: 82-42-280-6717
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Using Siplizumab to prevent immune issues in liver transplant patients with autoimmune liver disease
This study is testing if a new medication called siplizumab can help prevent immune problems in adults with autoimmune liver disease who are getting a liver transplant.
-
Improving outcomes in pediatric autoimmune liver disease
This study is trying to improve care for kids with autoimmune liver diseases by collecting and sharing information about their treatments and health to help doctors provide better support.
-
Biobank for cholestatic liver diseases
This study is collecting samples and health information from people with cholestatic liver diseases to see if it can help us better understand these conditions and improve how we detect and predict them.
-
Using MRI to predict outcomes in children with autoimmune liver disease
This study is testing if MRI scans can help predict how well children with autoimmune liver diseases will do over time.
-
Using MRI to assess liver damage in children with autoimmune liver disease
This study is testing if MRI scans can safely show liver damage in children with autoimmune liver diseases like PSC and AIH, helping doctors understand their condition better without needing invasive tests.
-
Additive Physical Activity for Hypothyroidism in Older Women with Glaucoma and Fatty Liver
We’re testing whether adding a treadmill-based exercise program to standard thyroid treatment helps improve health in older women who have subclinical hypothyroidism, glaucoma, and fatty liver.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.