Clinical trial Recruiting at 1 site Observational Ages 19 and up

Identifying liver disease-specific gut microbiomes

Official title: Exploration of Liver-gut Axis Through Identification of Liver Disease-specific Microbiome

Run by Chungnam National University Hospital · NCT06519162 · Data updated 2026-11-12

This study is trying to find out if certain gut bacteria are linked to chronic liver diseases in adults, including autoimmune hepatitis and primary biliary cholangitis, by analyzing blood and stool samples from patients and their household members.

Quick facts

Study typeObservational
Ages19 Years and up
SexAll
Enrollment3000 (estimated)
SponsorChungnam National University Hospital
Academic / other
Locations1 site (Daejeon, Jung-gu)
StatusRecruiting
StartedJuly 8, 2024
Main results expectedJuly 8, 2029
Study endsJuly 8, 2029
Registry record updatedMarch 20, 2026
Trial IDNCT06519162 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates include adults aged 19 and older diagnosed with autoimmune hepatitis, primary biliary cholangitis, primary sclerosing cholangitis, non-alcoholic fatty liver disease, or liver abscess.

Probably not a fit

Patients under the age of 19 or those who do not consent to participate will not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to identify gut microbiomes specific to patients with chronic refractory liver diseases, including autoimmune hepatitis and primary biliary cholangitis. Participants aged 19 and older, along with their household members, will provide blood and stool samples for analysis. The study will focus on understanding the gut-liver axis and its role in the pathogenesis and progression of liver diseases. The research will be conducted at Chungnam National University Hospital.

Why it matters

Potential benefit: If successful, this study could lead to improved understanding and management of chronic liver diseases through microbiome-targeted therapies.

How similar studies have gone: While studies on the gut-liver axis are emerging, this specific approach to identifying liver disease-specific microbiomes is relatively novel.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Adults aged 19 years and older diagnosed with autoimmune hepatitis, primary biliary cholangitis, primary sclerosing cholangitis, non-alcoholic fatty liver disease, or liver abscess, who have consented to participate in this study at Chungnam National University Hospital.
* Adults aged 19 years and older, who are cohabitants of patients diagnosed with autoimmune hepatitis, primary biliary cholangitis, primary sclerosing cholangitis, non-alcoholic fatty liver disease, or liver abscess, and have consented to participate in this study at Chungnam National University Hospital.

B. Exclusion

Exclusion Criteria:

* Individuals under the age of 19.
* Patients or guardians who do not consent to participate in the study

Where it's running

  • Chungnam National University Hospita
    Daejeon, Jung-gu, South Korea
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.