Condition

Liver Fibrosis clinical trials and research

• 26Clinical trials
• 37NIH research projects
• 1New in 30 days
• 43Countries

Newest Liver Fibrosis clinical trials

All recruiting trials (26)

• Endohepatology-based reclassification of treatment indication in high-risk MASLD

  This study tests whether an endohepatology assessment can change treatment decisions for adults with high-risk MASLD.

  Recruiting University Hospital Muenster · Münster · NCT07877272

• Umbilical cord stem cells added during Kasai to help biliary atresia

  This early-stage trial tests whether injecting umbilical cord mesenchymal stem cells during Kasai portoenterostomy is safe and helpful for infants with biliary atresia.

  Recruiting Phase 1 Dr Cipto Mangunkusumo General Hospital · Jakarta Pusat, DKI Jakarta · NCT07797673

• Automated Passive Case-Finding for Advanced Liver Fibrosis in MASLD

  This program automatically screens high‑risk adults aged 50–75 in primary care to see if they have advanced liver fibrosis and possible MASLD, using routine blood tests and reflex lab tests without extra work for clinicians.

  Recruiting Hospital General Universitario Gregorio Marañon · Madrid, Madrid · NCT07658755

• AZD2389 safety and dosing in adults with fatty liver disease and advanced liver scarring

  This study tests whether AZD2389 is safe and how it behaves in adults with steatotic liver disease and advanced fibrosis, comparing it to placebo over about six months.

  Recruiting at 22 sites Phase 2 AstraZeneca · Chandler, Arizona and 21 other locations · NCT07610837

• See if EUS-SWQ can accurately detect and grade liver fibrosis in adults with chronic liver disease

  This study tests whether the endoscopic ultrasound shear wave quantification (EUS-SWQ) can match liver biopsy results in adults with chronic liver disease to diagnose and stage fibrosis, and whether it offers safety and measurement advantages over FibroScan.

  Recruiting Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine · Shanghai · NCT07588854

• Non-invasive liver fibrosis testing in children and young adults with type III glycogen storage disease

  This project tries to see if non-invasive liver stiffness measurements (like elastography) can monitor liver fibrosis in children and young adults with type III glycogen storage disease.

  Recruiting University Hospital, Strasbourg, France · Strasbourg · NCT07303140

• Phycocyanin for liver protection in fibrosis and cirrhosis

  This trial will test whether a daily phycocyanin supplement can help adults with liver fibrosis or cirrhosis by lowering liver enzymes and improving liver stiffness.

  Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou · NCT07271576

• Single-cell and spatial mapping of liver degeneration and regeneration

  This project will try to use single-cell and spatial omics on preoperative blood and discarded liver tissue from people having liver surgery or biopsy to map how cells change during fatty liver, HBV infection, fibrosis, and cirrhosis.

  Recruiting Nanfang Hospital, Southern Medical University · Guangzhou, Guangdong · NCT07265544

• Non-invasive blood and imaging tests for metabolic liver disease

  This project tests whether blood tests and imaging scans can diagnose and stage metabolic-associated steatohepatitis (MASH) and liver fibrosis in adults with metabolic risk factors.

  Recruiting at 4 sites Foundation for the National Institutes of Health · Miami, Florida and 3 other locations · NCT07122700

• City and hospital collaboration to find early liver fibrosis in the Grenoble area

  This project tests using a simple FIB‑4 blood score followed by a FibroScan to find early liver fibrosis in adults referred by their primary-care doctor in the Grenoble area.

  Recruiting University Hospital, Grenoble · Grenoble and 1 other locations · NCT07031089

• Non-invasive approach to assess liver fibrosis in chronic hepatitis B patients

  This study is testing a new way to see if liver stiffness measurements can help predict if liver damage improves in people with chronic hepatitis B who have been treated with antiviral therapy.

  Recruiting Beijing Friendship Hospital · Beijing · NCT06874127

• Using MR elastography to assess liver fibrosis in chronic hepatitis B patients

  This study is testing if a new imaging technique called MR elastography can help doctors better understand liver damage in adults with chronic hepatitis B without needing a liver biopsy.

  Recruiting Shengjing Hospital · Shenyang, Liaoning · NCT06779058

• Testing Survodutide for Liver Disease in Patients with NASH/MASH

  This study is testing a new medication called survodutide to see if it can help adults with liver disease related to metabolic dysfunction feel better and improve their liver health.

  Recruiting at 497 sites Phase 3 Boehringer Ingelheim · Birmingham, Alabama and 531 other locations · NCT06632444

• Using AI to predict liver fibrosis severity

  This study is testing a new AI system to see if it can accurately predict the severity of liver fibrosis in people with chronic hepatitis B without needing invasive procedures.

  Recruiting Zhejiang Provincial People's Hospital · Hangzhou, Zhejiang · NCT06509230

• Improving liver health through metabolic surgery or medication

  This study is testing whether metabolic surgery or medication can improve liver health in people with liver disease and obesity.

  Recruiting at 2 sites Phase 4 The Cleveland Clinic · Phoenix, Arizona and 21 other locations · NCT06374875

• Very low-calorie ketogenic diet for patients with liver disease

  This study is testing whether a very low-calorie ketogenic diet can improve liver health and help with weight management in people with liver disease compared to a standard low-calorie Mediterranean diet.

  Recruiting University of Bologna · Bologna · NCT06308757

• Endoscopic sleeve gastroplasty for people with obesity and MASH

  This study will test whether endoscopic sleeve gastroplasty plus lifestyle changes helps adults with obesity and MASH lose weight and improve liver health compared with lifestyle changes alone.

  Recruiting at 2 sites Brigham and Women's Hospital · Boston, Massachusetts and 1 other locations · NCT06138821

• Investigating a new inflammatory marker's link to fatty liver disease and liver fibrosis

  This study is trying to see if a new blood marker can help doctors diagnose fatty liver disease and liver scarring in people who have these conditions.

  Recruiting Chongqing Medical University · Chongqing, Chongqing Municipality · NCT05974904

• Long-term treatment with hydronidone capsules for liver fibrosis in hepatitis B patients

  This study is testing if taking hydronidone capsules for a longer time can help people with liver fibrosis caused by hepatitis B feel better and improve their liver health.

  Recruiting at 23 sites Phase 3 Beijing Continent Pharmaceutical Co, Ltd. · Beijing, Beijing Municipality and 22 other locations · NCT05905172

• Screening for advanced liver fibrosis in patients with fatty liver disease or alcohol-related liver issues

  This study is testing two blood tests to see which one better helps doctors find advanced liver damage in people with fatty liver disease or alcohol-related liver problems.

  Recruiting University Hospital, Angers · Angers and 12 other locations · NCT05699018

• Effects of Ertugliflozin on liver fat and diabetes control in patients with fatty liver disease

  This study is testing if the medication Ertugliflozin can help adults with Type 2 Diabetes and fatty liver disease reduce liver fat and improve their blood sugar control.

  Recruiting Phase 4 Getz Pharma · Peshawar, KPK · NCT05644717

• Using thyroid hormone to treat liver disease in veterans

  This study is testing if low doses of thyroid hormone can help veterans with liver disease called NASH feel better and improve their liver health.

  Recruiting Phase 2 VA Office of Research and Development · Columbia, Missouri · NCT05526144

• Evaluating PHIN-214 for treating liver cirrhosis

  This study is testing a new treatment called PHIN-214 to see if it can safely help people with liver cirrhosis improve their liver function and manage related health issues.

  Recruiting at 9 sites Phase 1 PharmaIN · Chandler, Arizona and 8 other locations · NCT05490888

• Using simvastatin to treat liver fibrosis caused by alcohol

  This study tests if simvastatin, a cholesterol-lowering medication, can help people with liver damage from alcohol reduce their fibrosis.

  Recruiting Phase 2/3 Fundacion Clinic per a la Recerca Biomédica · Barcelona · NCT04971577

• Fast breath-hold MRI to measure liver collagen (macromolecular proton fraction)

  It tests whether a quick breath-hold MRI measurement called macromolecular proton fraction (MPF) can detect early-stage liver fibrosis in adults with or without liver disease.

  Recruiting Chinese University of Hong Kong · Hong Kong, Shatin · NCT04429100

• Using MRI to Measure Soft Tissue Stiffness

  This study is testing a new way to use MRI scans to see how stiff soft tissues like the liver and heart are, which could help diagnose conditions like liver fibrosis and heart failure more easily.

  Recruiting Ohio State University · Columbus, Ohio · NCT01757730

NIH-funded research (37)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Role of SMAD1/5/8 signaling in liver fibrosis

  This grant explores how specific liver cell signals influence scarring (fibrosis) in the liver, with a focus on people who have alcohol-related liver disease or related conditions.

  NIH research University of Arizona · Tucson, United States · NIH-11504353

• Targeting TGF-βRII to treat alcoholic liver fibrosis

  A study to test a new peptide that blocks a key fibrosis signal and a gene-silencing approach to help reverse liver fibrosis caused by alcohol use.

  NIH research University of Missouri Kansas City · Kansas City, United States · NIH-11466092

• Understanding how RNA binding proteins drive liver scarring and how to slow it down

  A researcher team is studying how certain RNA binding proteins, especially LARP6, regulate the liver’s scar-building process in alcoholic liver disease to identify potential ways to reduce fibrosis.

  NIH research Sanford Burnham Prebys Medical Discovery Institute · La Jolla, United States · NIH-11449893

• S100A9+ immune cells driving liver scarring in MASLD/MASH

  Affects people with MASLD/MASH may benefit from a better understanding of how certain immune cells contribute to liver fibrosis and how to stop it.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11429726

• Liver fibrosis test platform using patient-derived liver tissue to speed anti-fibrosis drugs

  A patient-focused liver fibrosis test platform is being developed to help speed the creation of medicines that treat liver scarring by using human-derived liver cells and tissue signals.

  NIH research Xylyx Bio, INC. · Brooklyn, United States · NIH-11413845

• Role of HK2 in liver scarring, fatty liver disease, and liver cancer

  A study in adults looks at how the enzyme HK2 helps drive liver scarring in NASH and may influence the development of liver cancer, with potential to point to new treatments.

  NIH research University of Illinois at Chicago · Chicago, UNITED STATES · NIH-11400510

• Novel Paxillin-FAK Inhibitors for Liver Fibrosis

  A new program is testing Paxillin-FAK inhibitors to slow or stop liver fibrosis in adults with liver diseases like alcoholic liver disease and MASH.

  NIH research Faknostics, LLC · Phoenix, United States · NIH-11387961

• Novel humanized liver model to study alcoholic liver fibrosis

  A research project aims to build a humanized liver model to better understand alcohol-related liver fibrosis and test potential therapies.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11373500

• ASO Therapy Targeting TILAM to Halt Liver Fibrosis

  Aims to develop antisense oligonucleotides that reduce a fibrosis-promoting RNA in liver cells to slow or stop scarring in chronic liver disease.

  NIH research Univ of Massachusetts Med Sch Worcester · Worcester, United States · NIH-11364945

• How the protein synectin may cause liver scarring (fibrosis)

  Researchers are exploring whether the protein synectin makes liver support cells move and lay down scar tissue in people with cirrhosis.

  NIH research Mayo Clinic Rochester · Rochester, United States · NIH-11332460

• Sterile inflammation, pyroptosis, and liver fibrosis link

  A study at UC San Diego is exploring how a specific inflammatory complex in the liver may drive fibrosis, with potential future implications for therapies.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11329537

• What causes liver scarring (fibrosis)

  The team is testing whether increased sugar-burning inside liver support cells makes them send out tiny protein-packed vesicles that worsen scarring, with the goal of helping people with liver fibrosis.

  NIH research Mayo Clinic Rochester · Rochester, United States · NIH-11325746

• Damaged mitochondrial signals that cause liver scarring in NASH

  This project looks at whether pieces of damaged mitochondria (mitochondrial DNA) trigger liver scarring in people with NASH.

  NIH research Beth Israel Deaconess Medical Center · Boston, United States · NIH-11312594

• How the liver enzyme CYP1B1 contributes to liver scarring

  This research tests whether blocking the liver enzyme CYP1B1 can stop the scar-forming cells that drive liver fibrosis in people with chronic liver injury.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11293462

• Non-Invasive Detection of Liver Fibrosis in Adults with diabetes using MASML AI

  A new AI-based test using standard blood tests aims to identify liver scarring early in adults with type 2 diabetes or related conditions to guide care.

  NIH research Methodist Hospital Research Institute · Houston, United States · NIH-11292924

• New drugs targeting paxillin and FAK to slow liver scarring

  New medicines that block the paxillin and FAK proteins are being developed to slow or reverse liver scarring in adults with alcoholic liver disease and related chronic liver conditions.

  NIH research Faknostics, LLC · Phoenix, United States · NIH-11249902

• Lab-grown human liver scar tissue to speed development of anti-fibrosis medicines

  This project makes lab models of human liver scarring using patient tissue so researchers can find better medicines for people with liver fibrosis.

  NIH research Xylyx Bio, INC. · Brooklyn, United States · NIH-11249098

• How PKM2 controls liver scarring

  This work looks at whether blocking the protein PKM2 can reduce liver scarring for people with chronic liver disease.

  NIH research VA Connecticut Healthcare System · West Haven, United States · NIH-11223302

• How scar-forming liver cells drive scarring and liver cancer growth

  This project tests whether blocking a fat-driven signaling loop inside scar-forming liver cells can reduce liver scarring and slow hepatocellular carcinoma in people with liver fibrosis or liver cancer.

  NIH research VA Greater Los Angeles Healthcare System · Los Angeles, United States · NIH-11212760

• How blood clotting affects liver scarring

  This study is looking at how certain proteins in your blood that help with clotting might affect liver damage and scarring, with the hope of finding new ways to treat liver diseases for people like you.

  NIH research Rutgers Biomedical and Health Sciences · Newark, UNITED STATES · NIH-11207318

• Investigating how specific signaling pathways affect liver fibrosis

  This study is looking at how certain signals in the liver can affect the health of liver cells and contribute to conditions like hemochromatosis and NASH, with the goal of finding new ways to help treat liver fibrosis.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11144567

• Hexokinase 2's role in liver scarring and NASH-related liver cancer

  Researchers are looking at whether a sugar-processing enzyme called HK2 causes liver scarring in people with NASH and helps liver cancer grow.

  NIH research University of Illinois at Chicago · Chicago, UNITED STATES · NIH-11140505

• Exploring how specific proteins affect liver cell activation in alcohol-related liver disease

  This study is looking at how two proteins, Wnt3a and Wnt5a, affect liver cells that can cause scarring in people with alcohol-related liver disease, with the hope of finding new ways to help treat this condition.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-11125748

• Understanding Liver Scarring in Cholestatic Diseases

  This research explores how specific cells cause liver scarring in conditions like primary sclerosing cholangitis and primary biliary cirrhosis.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11116851

• Understanding How Inflammation and Cell Death Lead to Liver Scarring

  This research explores how a specific immune process called the NLRP3 inflammasome contributes to liver scarring, also known as fibrosis.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11095871

• Understanding how liver cells contribute to fibrosis

  This study is looking at how a protein called synectin affects certain liver cells that play a role in liver scarring, with the hope of finding new treatments for people with liver fibrosis and cirrhosis.

  NIH research Mayo Clinic Rochester · Rochester, United States · NIH-11087515

• Understanding how liver fibrosis develops

  This study is looking into how a protein called PDGF helps cause liver fibrosis, which can lead to serious liver problems, and aims to find new ways to treat or even reverse this condition to help patients feel better.

  NIH research Mayo Clinic Rochester · Rochester, United States · NIH-11085291

• Investigating the role of CYP1B1 in liver fibrosis

  This study is looking at how a certain enzyme called CYP1B1 affects liver fibrosis, a condition that can happen after long-term liver damage, and aims to find new ways to help treat it by understanding how liver cells work together during this process.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11058420

• Investigating how mitochondrial signals contribute to liver fibrosis in NASH

  This study is looking at how changes in the tiny energy factories in your cells, called mitochondria, might affect the worsening of liver problems in people with non-alcoholic steatohepatitis (NASH), and it hopes to find new ways to help protect your liver.

  NIH research Beth Israel Deaconess Medical Center · Boston, United States · NIH-11049185

• New treatments for liver fibrosis using specific inhibitors

  This study is looking at new ways to help people with liver fibrosis by blocking certain proteins that cause liver damage, with the hope of slowing down or even reversing the condition.

  NIH research Faknostics, LLC · Phoenix, United States · NIH-11008655

• Creating a new test platform for liver fibrosis using patient-derived cells

  This study is working on a new way to test potential treatments for liver fibrosis by creating a lab model that closely resembles how the human liver behaves, which could help find better therapies for people living with this condition.

  NIH research Xylyx Bio, INC. · Brooklyn, United States · NIH-11008126

• Investigating how hexokinase 2 affects liver fibrosis and cancer development.

  This study is looking at how a protein called hexokinase 2 affects certain liver cells that can lead to liver scarring and cancer in people with a liver condition called NASH, with the goal of finding new ways to treat these diseases.

  NIH research University of Illinois at Chicago · Chicago, UNITED STATES · NIH-10979302

• Understanding how blood clotting affects liver scarring

  This study is looking at how certain blood clotting factors affect liver injury and inflammation, with the hope of finding new ways to help people with liver diseases like fibrosis, which causes scarring in the liver.

  NIH research Rutgers Biomedical and Health Sciences · Newark, UNITED STATES · NIH-10976425

• Measuring liver scarring using MRI and advanced computer techniques

  This study is looking for a gentle way to check for liver scarring in people with chronic liver disease using advanced MRI technology and smart computer programs, so you won’t need any painful biopsies.

  NIH research Cincinnati Childrens Hosp Med Ctr · Cincinnati, United States · NIH-10769797

• A model to understand and treat liver fibrosis

  This study is exploring new ways to treat liver fibrosis, a serious condition affecting the liver, by using tiny lab-grown liver models to test how well different drugs can help reduce the damage and improve health for people with liver diseases.

  NIH research Stanford University · Stanford, United States · NIH-10685178

• New antibodies to treat liver fibrosis

  This study is testing a new type of treatment using special antibodies to help people with liver fibrosis, a condition that can lead to serious liver problems, and aims to provide a safe option without the side effects of current treatments.

  NIH research Abalone Bio, INC. · Emeryville, UNITED STATES · NIH-10666671

• Understanding how genes affect liver fibrosis

  This study is looking at how a gene called Sirt6 affects liver fibrosis, which can happen with nonalcoholic fatty liver disease, and it aims to understand how things like diet can change liver cell behavior to help find new treatments for this condition.

  NIH research Indiana University Indianapolis · Indianapolis, United States · NIH-10640141

Related topics

Quick answers

How many Liver Fibrosis clinical trials are recruiting right now?

26, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 43 countries. The most sites are in China (9 trials), United States (7 trials), France (4 trials), Spain (4 trials), Italy (3 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 2, Phase 4: 2, Phase 3: 2, Phase 1: 2. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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