Investigating the role of a specific RNA in liver diseases related to bile flow issues
Official title: LncRNA H19 in Cholestatic Liver Diseases
Funded at Virginia Commonwealth University · NIH-10909545 · Data updated 2026-11-12
This study is looking at how a specific type of RNA might play a role in liver damage for people with primary sclerosing cholangitis (PSC), with the hope that understanding this could help find new ways to treat the condition.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Virginia Commonwealth University NIH-funded |
| Lab location | 1 site (Richmond, United States) |
| Project start | July 25, 2018 |
| Project end | August 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $629,582 |
| NIH project number | 2R56DK115377-05A1 |
| Project ID | NIH-10909545 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with primary sclerosing cholangitis or other cholestatic liver diseases.
✕Less likely to help
Patients with liver diseases not related to cholestasis or those without liver conditions may not benefit from this research.
What this research studies
This research focuses on primary sclerosing cholangitis (PSC), a serious liver disease characterized by inflammation and damage to bile ducts. The study aims to understand how long noncoding RNAs, particularly H19, contribute to liver injury by affecting bile formation and flow. Using advanced RNA sequencing techniques, researchers will analyze the expression of various noncoding RNAs in liver tissues to uncover their roles in cholestatic liver diseases. Patients may benefit from insights that could lead to new therapeutic strategies for managing PSC.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve liver health and quality of life for patients with cholestatic liver diseases.
How similar studies have gone: While the role of noncoding RNAs in liver diseases is an emerging field, previous studies have shown promising results in understanding their functions, indicating potential for success in this area.
Where this research is happening
-
Virginia Commonwealth University
Richmond, United States Active
Researchers
- Principal investigator: Zhou, Huiping Rose — Virginia Commonwealth University
- Study coordinator: Zhou, Huiping Rose
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.